Anukul Shenoy, PhD

Assistant Professor, Microbiology & Immunology
Assistant Professor, Internal Medicine - Pulmonary & Critical Care Medicine

6704A Medical Science Building II

Biography

Dr. Anukul Shenoy completed his BS and MS in Biotechnology from Ruia College (University of Mumbai, India) before moving to USA and starting his doctoral training with Dr. Carlos Orihuela at Univ. of Texas Health Center at San Antonio in 2014. In 2015, he moved with Dr. Orihuela to the Dept. of Microbiology at University of Alabama at Birmingham (UAB) where he went on to complete his PhD in 2017. His doctoral work was focused on understanding host-pathogen interactions involved in pneumococcal infections. In 2018, he joined Dr. Jay Mizgerd’s lab at the Pulmonary Center, Boston University School of Medicine where his work focused on elucidating the cellular and molecular mechanisms underlying lung epithelial and resident CD4  T cell communication in context of pulmonary immunity during health and disease. Dr. Shenoy started as an Assistant Professor in the Department of Microbiology and Immunology, and the Division of Pulmonary and Critical Care Medicine at the University of Michigan Medical School at Ann Arbor in April 2023 where he leads the Shenoy Lab of Barrier Immunobiology (SLOBI).

Areas of Interest

Effective tissue immunity requires effective clearance of noxious agents coupled with timely resolution of inflammation to allow tissue repair and regeneration, ability to remember the initial transgressor, and then prompt, apt responsiveness to subsequent re-encounter. All these processes need finely regulated, intimate crosstalk between the barrier epithelial cells and the noxious stimuli (microbes, allergens, cancer cells), innate immune cells (like macrophages, neutrophils, etc.), and adaptive immune cells (like T cells). A prime example of such a malleable and effective barrier tissue system is the lung and their epithelial cells. An average human adult breathes in ~11,000 liters of air on a daily basis wherein each breath is distributed over an epithelial surface area equivalent to a tennis court and each bout of this "life-giving" gas exchange happens across an alveolar epithelial-capillary barrier which is less than 1micron thick. Thus, lung epithelial cells have to eliminate airborne agents as they pass down the airway tree to ensure near sterility of the air reaching the alveoli for gas exchange with the circulatory system. To do so, we have evolved an intricate system where distinct lung epithelial and stem cells occupying discrete niches within the mammalian lungs not only act as physical barriers and innate effector cells (by producing mucus, detoxifying enzymes, surfactants, and antimicrobial peptides, etc.) but also communicate with neighboring structural and immune (innate and adaptive) cells to program a well-regulated immune and tissue repair response as part of pulmonary immunity.

The Shenoy Lab of Barrier Immunobiology is interested in mechanistically understanding exactly how this intimate crosstalk between the barrier epithelial cells, the noxious stimuli, innate immune cells (like macrophages, neutrophils, etc.), and adaptive immune cells (like T cells) is finely regulated to ensure tissue functionality and repair in the short and long term post distinct pulmonary insults.

Honors & Awards

NIH/NHLBI K99/R00 Pathway to Independence Award Fellow 2022 - 2026

ATS Pulmonary Infection & TB Science and Innovation Center Rising Star Award 2022

American Association of Immunologists 2022 Trainee Abstract Award 2022

Boston University Professional Development & Postdoctoral Affairs Travel Award 2022

American Association of Immunologists Young Investigator Award 2021

Intersections Science Associate for November 2021

American Association of immunologists 2021 Trainee Abstract Award 2021

ATS Allergy, Immunology & Inflammation Science and Innovation Center Award 2021

American Thoracic Society 2021 Abstract Scholarship

Inaugural Intersections Science Associate for January 2021

American Thoracic Society 2019 Abstract Scholarship

UAB Dept of Microbiology David E. Wells Symposium Graduate Student Speaker 2017

The Hiramoto Travel Award, UAB Dept of Microbiology 2017

The Richard and Mary Finkelstein Student Travel Grant, ASM 2016

Gail H. Cassell Microbiology Scholarship Endowment Award 2015, 2016, 2017

Sir Ratan Tata Trust National Merit Scholarship for Academic Excellence 2012, 2013, 2014

The University of Mumbai Late Smt. Gunwantiben K. Mehta Award 2009 - 2014

Ramnarain Ruia College Smt. Yamunabai Hirlekar Award 2013

Ramnarain Ruia College Kridabhushan Award 2011

Ramnarain Ruia College of Science Alumni Association Best Student Award 2010

 

Published Articles or Reviews

Web Sites