Areas of Interest
Dr. Moore’s laboratory has several main areas of research interest. One focus is the regulation of innate and adaptive immunity post-stem cell transplantation. Her laboratory uses murine models and human clinical samples to study alterations to dendritic cell function, Th1 vs Th17 skewing in response to herpesvirus infections, the role of IL-17 in development of pneumonitis and fibrosis and how viral infections impact development of graft versus host disease. For this work she focuses on murine herpesviruses. Her laboratory is also interested in how the process of transplantation alters innate immune cell function to impair clearance of bacterial lung infections. Specifically this work is focused on prostaglandin signaling in macrophages and neutrophils post-transplant.
She has an active project related to secondary bacterial infection in the lung following influenza infection. This project focuses on CCR2 and TLR9 signaling and how the innate immune response is altered in the presence of influenza infection.
Another area of interest is the pathogenesis of pulmonary fibrosis. In this work, her laboratory has studied how development of fibrosis in the lungs alters lung microbiota, how herpesvirus infections exacerbate fibrosis and how monocyte/macrophages impact development of disease. Current projects are focused on the role of myeloid-derived HB-EGF in driving disease pathogenesis. There is also a project on macrophage-derived IL-10 regulating epithelial apoptosis in the setting of lung injury and fibrosis. She also studies how the fibrotic lung milieu impacts the function of innate immune cells to clear bacterial infections.
Finally, her laboratory has active collaborations with Dr. Katherine Gallagher to study diabetic wound healing. In this work they are interested in prostaglandin signaling and alterations to inflammatory macrophages that influence wound healing. Additionally, they study how diabetes complicates the clearance of bacteria from wounds.