1500 E. Medical Center Drive
Ann Arbor, MI 48109
Available to mentor
Dr. Mobley received his PhD at the University of Louisville School of Medicine and conducted postdoctoral work at the University of Maryland School of Medicine in Biochemistry and Vaccine Development, after which he joined the faculty in the Division of Infectious Diseases and rose to the rank of Professor of Microbiology and Immunology. After 23 years at Maryland, Dr. Mobley was named Chair of the Department of Microbiology and Immunology at the University of Michigan Medical School in 2004, serving in this role until 2019. Dr. Mobley’s research focuses on uropathogenic E. coli and Proteus mirabilis, but has also studied Helicobacter pylori and Gram-negative bacterial species causing bacteremia including E. coli, Klebsiella pneumoniae, Acinetobacter baumannii, Citrobacter freundii, and Serratia marcescens.
Mobley Lab
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BiochemistryUniversity of Maryland School of Medicine, Department of Biological Chemistry, 1984
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Bacterial GeneticsUniversity of Maryland School of Medicine, Center for Vaccine Development, 1984
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PhDUniversity of Louisville School of Medicine, Louisville, 1981
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MSUniversity of Louisville School of Medicine, Louisville, 1977
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BSEmory University School of Medicine, Atlanta, 1975
Molecular mechanisms of bacterial pathogenesis of urinary tract infection and bacteremia; bacterial genetics; E. coli, Proteus mirabilis, Acinetobacter baumannii
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Mobley H. 2024 Apr 27;PresentationBacteremia Fitness Factors in Gram-Negative Bacilli
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Pearson MM, Shea AE, Pahil S, Smith SN, Forsyth VS, Mobley HLT. Infect Immun, 2023 Nov 16; 91 (11): e0035523Journal ArticleOrgan agar serves as physiologically relevant alternative for in vivo bacterial colonization.
DOI:10.1128/iai.00355-23 PMID: 37850748 -
Brown AN, Anderson MT, Smith SN, Bachman MA, Mobley HLT. mBio, 2023 Oct 31; 14 (5): e0144823Journal ArticleConserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia.
DOI:10.1128/mbio.01448-23 PMID: 37681955 -
Khadka S, Ring BE, Walker RS, Krzeminski LR, Pariseau DA, Hathaway M, Mobley HLT, Mike LA. mSphere, 2023 Oct 24; 8 (5): e0028823Journal ArticleUrine-mediated suppression of Klebsiella pneumoniae mucoidy is counteracted by spontaneous Wzc variants altering capsule chain length.
DOI:10.1128/msphere.00288-23 PMID: 37610214 -
Frick-Cheng AE, Shea AE, Roberts JR, Smith SN, Ohi MD, Mobley HLT. bioRxiv, 2023 Sep 28;Journal ArticleAltered motility in response to iron-limitation is regulated by lpdA in uropathogenic E. coli CFT073.
DOI:10.1101/2023.09.27.559868 PMID: 37808639 -
Holmes CL, Wilcox AE, Forsyth V, Smith SN, Moricz BS, Unverdorben LV, Mason S, Wu W, Zhao L, Mobley HLT, Bachman MA. PLoS Pathog, 2023 Jul; 19 (7): e1011233Journal ArticleKlebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress.
DOI:10.1371/journal.ppat.1011233 PMID: 37463183 -
Pearson MM, Shea AE, Pahil S, Smith SN, Forsyth VS, Mobley HLT. 2023 May 19;PreprintOrgan agar serves as physiologically relevant alternative for in vivo colonization.
DOI:10.21203/rs.3.rs-2777869/v1 PMID: 37293055 -
Brown A, Anderson M, Smith S, Bachman M, Mobley H. 2023 bioRxiv,PreprintConserved Metabolic Regulator ArcA Responds to Oxygen Availability, Iron Limitation, and Cell Envelope Perturbations during Bacteremia
DOI:10.1101/2023.04.18.537286