Harry L Mobley, PhD
Frederick G Novy Distinguished University Professor of Microbiology and Immunology
Frederick Novy Collegiate Professor
Professor of Microbiology and Immunology
Microbiology and Immunology
1500 E. Medical Center Drive
Ann Arbor, MI 48109
[email protected]

Available to mentor

Harry L Mobley, PhD
Professor
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Dr. Mobley received his PhD at the University of Louisville School of Medicine and conducted postdoctoral work at the University of Maryland School of Medicine in Biochemistry and Vaccine Development, after which he joined the faculty in the Division of Infectious Diseases and rose to the rank of Professor of Microbiology and Immunology. After 23 years at Maryland, Dr. Mobley was named Chair of the Department of Microbiology and Immunology at the University of Michigan Medical School in 2004, serving in this role until 2019. Dr. Mobley’s research focuses on uropathogenic E. coli and Proteus mirabilis, but has also studied Helicobacter pylori and Gram-negative bacterial species causing bacteremia including E. coli, Klebsiella pneumoniae, Acinetobacter baumannii, Citrobacter freundii, and Serratia marcescens.

    Links
    • Mobley Lab
    Qualifications
    • Biochemistry
      University of Maryland School of Medicine, Department of Biological Chemistry, 1984
    • Bacterial Genetics
      University of Maryland School of Medicine, Center for Vaccine Development, 1984
    • PhD
      University of Louisville School of Medicine, Louisville, 1981
    • MS
      University of Louisville School of Medicine, Louisville, 1977
    • BS
      Emory University School of Medicine, Atlanta, 1975
    Research Overview

    Molecular mechanisms of bacterial pathogenesis of urinary tract infection and bacteremia; bacterial genetics; E. coli, Proteus mirabilis, Acinetobacter baumannii

    Recent Publications See All Publications
    • Presentation
      Bacteremia Fitness Factors in Gram-Negative Bacilli
      Mobley H. 2024 Apr 27;
    • Journal Article
      Organ agar serves as physiologically relevant alternative for in vivo bacterial colonization.
      Pearson MM, Shea AE, Pahil S, Smith SN, Forsyth VS, Mobley HLT. Infect Immun, 2023 Nov 16; 91 (11): e0035523 DOI:10.1128/iai.00355-23
      PMID: 37850748
    • Journal Article
      Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia.
      Brown AN, Anderson MT, Smith SN, Bachman MA, Mobley HLT. mBio, 2023 Oct 31; 14 (5): e0144823 DOI:10.1128/mbio.01448-23
      PMID: 37681955
    • Journal Article
      Urine-mediated suppression of Klebsiella pneumoniae mucoidy is counteracted by spontaneous Wzc variants altering capsule chain length.
      Khadka S, Ring BE, Walker RS, Krzeminski LR, Pariseau DA, Hathaway M, Mobley HLT, Mike LA. mSphere, 2023 Oct 24; 8 (5): e0028823 DOI:10.1128/msphere.00288-23
      PMID: 37610214
    • Journal Article
      Altered motility in response to iron-limitation is regulated by lpdA in uropathogenic E. coli CFT073.
      Frick-Cheng AE, Shea AE, Roberts JR, Smith SN, Ohi MD, Mobley HLT. bioRxiv, 2023 Sep 28; DOI:10.1101/2023.09.27.559868
      PMID: 37808639
    • Journal Article
      Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress.
      Holmes CL, Wilcox AE, Forsyth V, Smith SN, Moricz BS, Unverdorben LV, Mason S, Wu W, Zhao L, Mobley HLT, Bachman MA. PLoS Pathog, 2023 Jul; 19 (7): e1011233 DOI:10.1371/journal.ppat.1011233
      PMID: 37463183
    • Preprint
      Organ agar serves as physiologically relevant alternative for in vivo colonization.
      Pearson MM, Shea AE, Pahil S, Smith SN, Forsyth VS, Mobley HLT. 2023 May 19; DOI:10.21203/rs.3.rs-2777869/v1
      PMID: 37293055
    • Preprint
      Conserved Metabolic Regulator ArcA Responds to Oxygen Availability, Iron Limitation, and Cell Envelope Perturbations during Bacteremia
      Brown A, Anderson M, Smith S, Bachman M, Mobley H. 2023 bioRxiv, DOI:10.1101/2023.04.18.537286
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