1150 W Med Ctr Dr
Ann Arbor, MI 48109-5620
Available to mentor
Dr. Spindler worked on two viruses in graduate school: the bacteriophage ΦX174 and vesicular stomatitis virus (VSV). For her dissertation with John Holland, she investigated the virus evolution during persistent infection by VSV. Dr. Sprindler moved to UCLA for her postdoctoral work on adenoviruses with Arnie Berk, where she used molecular biology tools to characterize viral gene expression and viral replication.
Since the human adenoviruses are species-specific, in order to study viral pathogenesis she began studies with mouse adenovirus (MAV-1) in mice. Dr. Spindler’s first faculty position was in the Department of Genetics at the University of Georgia. Eighty-three people worked on MAV-1 in the Spindler lab in Athens. In 2002 Kathy moved to a position as Professor in the Department of Microbiology & Immunology at the University of Michigan. So far >100 people have worked in the Spindler lab in Ann Arbor.
Dr. Spindler’s research encompasses virology, pathogenesis, molecular biology, genetics, immunology and even some biochemistry. In addition to being a member of the U-M M&I Department, she is a member of the Cellular and Molecular Biology Training Program and the Molecular Mechanisms of Microbial Pathogenesis Training Program. She is Secretary-Treasurer of the American Society for Virology and is a member of the TWiV podcast team ("This Week in Virology").
Spindler Lab
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Postdoctoral ScholarUniversity of California, Los Angeles, Molecular Biology Institute, Dept. of Microbiology, 1985
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PhDUniversity of California, San Diego, La Jolla, CA, 1981
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BSPurdue University West Lafayette, West Lafayette, 1975
Dr. Spindler has a longstanding interest in determining viral and host determinants of pathogenesis. Initial research included characterizing the molecular genetics of mouse adenovirus type 1 (MAV-1). Subsequent projects have included identifying host genetics of mouse susceptibility to MAV-1, mechanisms of MAV-1 disruption of the blood-brain barrier, and innate immune responses to MAV-1 infection. Current research addresses how MAV-1 interacts with host eIF2-alpha kinases and successfully replicates in the face of these host antiviral responses. A collection of MAV-1 mutant viruses and reagents is combined with existing mouse mutants in eIF2-alpha kinases to determine their importance to the outcome of viral infections.
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Tejera-Hernández B, Goodman DE, Nevarez JM, Spindler KR. J Virol, 2023 Oct 31; 97 (10): e0126523Journal ArticleCorrection for Tejera-Hernández et al., "Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation".
DOI:10.1128/jvi.01265-23 PMID: 37787532 -
Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu S-L, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou J-H, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. mSphere, 2023 Apr 20; 8 (2): e0003423Journal ArticleVirology under the Microscope-a Call for Rational Discourse.
DOI:10.1128/msphere.00034-23 PMID: 36700653 -
Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu S-L, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou J-H, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. J Virol, 2023 Feb 28; 97 (2): e0008923Journal ArticleVirology under the Microscope-a Call for Rational Discourse.
DOI:10.1128/jvi.00089-23 PMID: 36700640 -
Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu S-L, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou J-H, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. mBio, 2023 Feb 28; 14 (1): e0018823Journal ArticleVirology under the Microscope-a Call for Rational Discourse.
DOI:10.1128/mbio.00188-23 PMID: 36700642 -
Tejera-Hernández B, Goodman DE, Nevarez JM, Spindler KR. J Virol, 2022 Apr 13; 96 (7): e0206321Journal ArticleMouse Adenovirus Type 1 E4orf6 Induces PKR Degradation.
DOI:10.1128/jvi.02063-21 PMID: 35285681 -
Hemmi S, Spindler KR. FEBS Lett, 2019 Dec; 593 (24): 3649 - 3659.Journal ArticleMurine adenoviruses: tools for studying adenovirus pathogenesis in a natural host.
DOI:10.1002/1873-3468.13699 PMID: 31777948 -
Goodman DE, Pretto CD, Krepostman TA, Carnahan KE, Spindler KR. mBio, 2019 Apr 23; 10 (2):Journal ArticleEnhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR).
DOI:10.1128/mBio.00668-19 PMID: 31015330 -
Goffin E, Javaux J, Destexhe E, Pretto CD, Spindler KR, Machiels B, Gillet L. J Virol, 2019 Jul 1; 93 (13):Journal ArticleOral Vaccination with Replication-Competent Adenovirus in Mice Reveals Dissemination of the Viral Vaccine beyond the Gastrointestinal Tract.
DOI:10.1128/JVI.00237-19 PMID: 30996103
