Kathleen Collins 2022

Kathleen Collins, M.D., Ph.D.

Professor, Internal Medicine
Professor, Microbiology and Immunology
Director, MSTP
Associate Dean, Physician Scientist Education and Training, she/her/hers

3510D MSRB I

1150 West Medical Center Drive

Ann Arbor, MI 48104

734-615-1320

Administrative Contact

Biography

I have four cats, two sons and many fish.  I enjoy reading, working out and traveling to interesting places.

Appointments

Cellular and Molecular Biology Graduate Program
Immunology Graduate Program

Areas of Interest

The Collins laboratory focuses on the molecular mechanisms underlying HIV persistence, immune evasion and chronic immune activation. HIV causes a lethal syndrome (acquired immunodeficiency syndrome) characterized by CD4+ T cell depletion and resultant immunodeficiency. HIV has caused a worldwide epidemic that has killed millions of people and continues to infect about 40,000 people each year in this country. The long-term goal of our research program is to provide improved treatments for people with HIV/AIDS.  For more information, see:. https://collins.lab.medicine.umich.edu

Honors & Awards

2022    University of Michigan Distinguished Faculty achievement Award 

2019    JCI Insight Editor in Chief

2019    Dean’s Award for Basic Science Research

2018    Taubman Senior Scholar Award

2018    Token of Appreciation from Medical Students Award

2016    National Academy of Medicine

2014    Internal Medicine Collegiate Chair of HIV Research

2014    Taubman Scholar Award

2012    Association of American Physicians

2011    League of Research Excellence, U-M Medical School

2005    American Society for Clinical Investigation

1999    Pew Scholars Award

1998    Massachusetts Infectious Disease Society Maxwell Finland Young Investigator Award for Excellence in Research

1986    Medical Scientist Training Program Award

Grants

5R01AI149669-03 - Integrative Single-Cell Analysis of Transcriptome, Epigenome, and Lineage in HIV Latency and Activation

5R01AI148383-04 - Development of natural product inhibitors of Nef for clearance of HIV reservoirs

5R01DK129058-02 - Molecular mechanisms underlying HIV related intestinal epithelial barrier dysfunction

5R01AI148084-04 - Cellular Reservoirs of HIV

Published Articles or Reviews

Selected Publications

  1. Li, C Virgilio, MV, Collins, KL, Welch, JD. Single-cell multi-omic velocity infers dynamic and decoupled gene regulation. Nature Biotechnology 2022; in press.
  2. Painter MM, Zimmerman GE, Merlino MS, Robertson AW, Terry VH, Ren X, McLeod MR, Gomez-Rodriguez L, Garcia KA, Leonard JA, Leopold KE, Neevel AJ, Lubow J, Olson E, Piechocka-Trocha A, Collins DR, Tripathi A, Raghavan M, Walker BD, Hurley JH, Sherman DH, Collins KL. Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23835-23846. doi: 10.1073/pnas.2008615117. Epub 2020 Sep 8. PMID: 32900948; PMCID: PMC7519347.
  3. Lubow J, Virgilio MC, Merlino M, Collins DR, Mashiba M, Peterson BG, Lukic Z, Painter MM, Gomez-Rivera F, Terry V, Zimmerman G, Collins KL. Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages. Elife. 2020 Mar 2;9:e51035. doi: 10.7554/eLife.51035. PMID: 32119644; PMCID: PMC7051176.
  4. Zaikos TD, Terry VH, Sebastian Kettinger NT, Lubow J, Painter MM, Virgilio MC, Neevel A, Taschuk F, Onafuwa-Nuga A, McNamara LA, Riddell J 4th, Bixby D,nMarkowitz N, Collins KL. Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients. Cell Rep. 2018 Dec 26;25(13):3759-3773.e9. doi: 10.1016/j.celrep.2018.11.104. PubMed PMID: 30590047
  5. Zaikos TD, Painter MM, Sebastian NT, Terry VH, Collins KL. Class 1-selective histone deacetylase inhibitors enhance HIV latency reversal while preserving the activity of HDAC isoforms necessary for maximal HIV gene expression. J Virol. 2018 Jan 3. pii: JVI.02110-17. doi: 10.1128/JVI.02110-17. [Epub ahead of print] PubMed PMID: 29298886.
  6. Painter MM, Zaikos TD, Collins KL. Quiescence promotes latent HIV infection and resistance to reactivation from latency with histone deacetylase inhibitors. J Virol. 2017 Oct 11. pii: JVI.01080-17. doi: 10.1128/JVI.01080-17. [Epub ahead of print] PubMed PMID: 29021396.
  7. Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell J 4th, Bixby D, Markowitz N, Morrison SJ, Collins KL. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. PLoS Pathog. 2017 Jul 21;13(7):e1006509. doi: 10.1371/journal.ppat.1006509. [Epub ahead of print] PubMed PMID: 28732051.
  8. Collins DR, Lubow J, Lukic Z, Mashiba M, Collins KL. Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes. PLoS Pathog. 2015 Jul 17;11(7):e1005054. doi: 10.1371/journal.ppat.1005054. eCollection 2015 Jul.PubMed PMID: 26186441; PubMed Central PMCID: PMC4506080.
  9. Mashiba M, Collins DR, Terry VH, Collins KL. Vpr Overcomes Macrophage-Specific Restriction of HIV-1 Env Expression and Virion Production. Cell Host Microbe. 2014 Dec 10;16(6):722-35. doi: 10.1016/j.chom.2014.10.014. Epub 2014 Nov 26. PubMed PMID: 25464830.
  10. Kulpa, D.A., Del Cid, N., Peterson K., and Collins, K.L., (2013) Adaptor protein 1 directs MHC-I into a cross-presentation pathway, J. Virol.May 14. [Epub ahead of print] PubMed PMID: 23678182. (Selected by the editors for inclusion in JVI “Spotlight”, a feature that highlights research articles of significant interest from the current issue.)
  11. McNamara L.A., Sebastian, N., Riddell, J, Bixby, D., and Collins, K.L., (2013) CD133+ HPCs harbor HIV genomes in a subset of optimally treated people with long-term viral suppression. J Infect Dis., Apr 22. [Epub ahead of print] PubMed PMID: 23554378. (Highlighted with an Editorial Commentary in J Infect Dis.)
  12. McNamara L.A, Ganesh J.A., Collins K.L., (2012) Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF-kB Activation.   J Virol. 2012 Jun 20. McNamara, L.A., Onafuwa-Nuga, A.,
  13. Heigele, A., Schindler, M., Gnanadurai, C.W., Leonard, J.A., Collins, K.L. Frank Kirchhoff, F., (2012) Down-modulation of CD8αß is a fundamental activity of primate lentiviral Nef proteins. J. Virol. Jan;86(1):36-48. Epub 2011 Oct 19. PubMed PMID: 22013062; PubMed Central PMCID: PMC3255914.
  14. Wonderlich, E.R. Kulpa, D.A., Leonard, J.A., Leopold, K. and Collins, K.L., (2011) ARF-1activity is required to recruit AP-1 to the MHC-I cytoplasmic tail and disrupt MHC-I trafficking in HIV-1 infected primary T cells, J. Virol. Dec;85(23):12216-26.  Epub 2011 Sep 14. PubMed PMID: 21917951; PubMed Central PMCID: PMC3209341.
  15. Norman, J.M., McNamara, L.A., Onafuwa-Nuga, Mashiba, M., Chiari, E. and Collins K.L., (2011) The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells, Nature Immunology, Aug 28;12(10):975-83.  doi: 10.1038/ni.2087. [Epub ahead of print] PubMed PMID: 21874023.  (Highlighted with News and Views in Nature Immunology; selected as Nature Immunology article of the month).
  16. Leonard, J.A., Filzen, T., Carter, C.C., Schaefer, M., Collins, K.L., (2011) The HIV-1 Nef protein disrupts intracellular trafficking of MHC-I, CD4, CD8 and CD28 by distinct pathways that share common elements, J. Virol.  Jul 85(14):6867-81.  Epub 2011 May 4.  PubMed PMID: 21543478, PubMed Central PMCID:PMC3126561.
  17. Carter, C.C., McNamara, L.A., Onafuwa-Nuga, A., Shackleton, M., Riddell, J., Bixby, D., Morrison, S.J., and Collins, K.L., (2011) HIV-1 utilizes the CXCR4 chemokine receptor to infect multi-potent hematopoietic stem cells, Cell Host & Microbe, Mar 17;9(3):223-34. (Highlighted in Cell Host and Microbe, Nature Reviews Microbiology and Cell podcast).
  18. Garcia-Perez, J.L., Morell, M., Scheys, J.O., Kulpa, D.A., Morell, S., Carter, C.C., Kim, J.K., Hammer, G.D., Collins, K.L., Andrews, P.W., O’Shea, K.S., Menendez, P., and Moran, J.V., (2010) Epigenetic silencing of LINE-1 retrotransposition events in human embryonic carcinoma cell lines, Nature, Aug 5;466(7307):769-73.
  19. Carter, C.C., Onafuwa-Nuga, A., Riddell, J., Bixby, D., Savona, M.R. and Collins, K.L., (2010) HIV-1 Infects Multipotent Progenitor Cells Causing Cell Death and Establishing Latent Cellular Reservoirs, Nature Medicine, Apr;16(4):446-51. Epub 2010 Mar 7, PubMed PMID: 20208541. (Highlighted in Nature, Cell, Science and Nature Reviews Microbiology)

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