Error message

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  • Opening and ending tag mismatch: input line 228 and form on line 230. Error code: 76
  • Opening and ending tag mismatch: form line 227 and div on line 239. Error code: 76
  • EntityRef: expecting ';' on line 247. Error code: 23
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  • Opening and ending tag mismatch: input line 266 and div on line 272. Error code: 76
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  • Opening and ending tag mismatch: input line 1013 and div on line 1019. Error code: 76
  • Opening and ending tag mismatch: input line 1043 and div on line 1049. Error code: 76
  • Opening and ending tag mismatch: input line 1073 and div on line 1079. Error code: 76
  • Opening and ending tag mismatch: input line 1103 and div on line 1109. Error code: 76
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  • Opening and ending tag mismatch: input line 1461 and div on line 1467. Error code: 76
  • Opening and ending tag mismatch: input line 1490 and div on line 1496. Error code: 76
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  • Opening and ending tag mismatch: input line 1697 and div on line 1703. Error code: 76
  • Opening and ending tag mismatch: input line 1727 and div on line 1733. Error code: 76
  • Specification mandate value for attribute checked on line 1759. Error code: 41
  • Opening and ending tag mismatch: input line 1759 and li on line 1761. Error code: 76
  • Opening and ending tag mismatch: input line 1763 and li on line 1765. Error code: 76
  • Opening and ending tag mismatch: li line 1762 and ul on line 1766. Error code: 76
  • Opening and ending tag mismatch: input line 1771 and div on line 1772. Error code: 76
  • Opening and ending tag mismatch: input line 1841 and form on line 1842. Error code: 76
  • Opening and ending tag mismatch: input line 1840 and section on line 1844. Error code: 76
  • Opening and ending tag mismatch: form line 1839 and main on line 1846. Error code: 76
  • Entity 'ensp' not defined on line 1935. Error code: 26
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  • Opening and ending tag mismatch: input line 1988 and body on line 1997. Error code: 76
  • Opening and ending tag mismatch: li line 1758 and html on line 1998. Error code: 76
  • Premature end of data in tag ul line 1757 on line 1999. Error code: 77
  • Premature end of data in tag div line 1754 on line 1999. Error code: 77
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  • Premature end of data in tag div line 1370 on line 1999. Error code: 77
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  • Premature end of data in tag div line 980 on line 1999. Error code: 77
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  • Premature end of data in tag div line 920 on line 1999. Error code: 77
  • Premature end of data in tag div line 890 on line 1999. Error code: 77
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  • Premature end of data in tag div line 830 on line 1999. Error code: 77
  • Premature end of data in tag div line 801 on line 1999. Error code: 77
  • Premature end of data in tag div line 771 on line 1999. Error code: 77
  • Premature end of data in tag div line 741 on line 1999. Error code: 77
  • Premature end of data in tag div line 711 on line 1999. Error code: 77
  • Premature end of data in tag div line 681 on line 1999. Error code: 77
  • Premature end of data in tag div line 651 on line 1999. Error code: 77
  • Premature end of data in tag div line 621 on line 1999. Error code: 77
  • Premature end of data in tag div line 591 on line 1999. Error code: 77
  • Premature end of data in tag div line 561 on line 1999. Error code: 77
  • Premature end of data in tag div line 532 on line 1999. Error code: 77
  • Premature end of data in tag div line 502 on line 1999. Error code: 77
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  • Premature end of data in tag div line 442 on line 1999. Error code: 77
  • Premature end of data in tag div line 412 on line 1999. Error code: 77
  • Premature end of data in tag div line 382 on line 1999. Error code: 77
  • Premature end of data in tag div line 352 on line 1999. Error code: 77
  • Premature end of data in tag div line 322 on line 1999. Error code: 77
  • Premature end of data in tag div line 292 on line 1999. Error code: 77
  • Premature end of data in tag div line 263 on line 1999. Error code: 77
  • Premature end of data in tag div line 258 on line 1999. Error code: 77
  • Premature end of data in tag div line 224 on line 1999. Error code: 77
  • Premature end of data in tag section line 147 on line 1999. Error code: 77
  • Premature end of data in tag main line 145 on line 1999. Error code: 77
  • Premature end of data in tag body line 72 on line 1999. Error code: 77
  • Premature end of data in tag link line 47 on line 1999. Error code: 77
  • Premature end of data in tag link line 45 on line 1999. Error code: 77
  • Premature end of data in tag link line 43 on line 1999. Error code: 77
  • Premature end of data in tag link line 27 on line 1999. Error code: 77
  • Premature end of data in tag link line 21 on line 1999. Error code: 77
  • Premature end of data in tag link line 19 on line 1999. Error code: 77
  • Premature end of data in tag meta line 15 on line 1999. Error code: 77
  • Premature end of data in tag meta line 14 on line 1999. Error code: 77
  • Premature end of data in tag meta line 13 on line 1999. Error code: 77
  • Premature end of data in tag meta line 10 on line 1999. Error code: 77
  • Premature end of data in tag meta line 9 on line 1999. Error code: 77
  • Premature end of data in tag head line 8 on line 1999. Error code: 77
  • Premature end of data in tag html line 7 on line 1999. Error code: 77

Kathryn A. Eaton, Ph.D., DVM

Professor
734-936-3883

Areas of Interest

Immunopathogenesis of Helicobacter pylori Pathogenesis of Shigatoxigenic Escherichia coli

Dr. Eaton is a board-certified veterinary pathologist (diplomate of the American College of Veterinary Pathologists) with research interests in bacterial pathogens of the gastrointestinal tract, host-pathogen interactions, and intestinal immunity. Her laboratory has three main research directions.

Helicobacter pylori

H. pylori is a bacterial pathogen of humans that causes gastritis, peptic ulcer, and gastric cancer. It is found naturally only in the human stomach, and is now thought to cause disease via induction of an exuberant mucosal immune response. Dr. Eaton has been studying H. pylori for more than 20 years and has used several animal models including germ-free piglets, gerbils, and mice to investigate a variety of bacterial colonization and virulence factors as well as aspects of host immune response. We currently use an adoptive transfer mouse model in which T cells from immunocompetent mice are adoptively transferred into H. pylori-infected immunodeficient mice. Non-transferred immunodeficient mice support large numbers of bacteria in their stomachs with no gastritis, adaptive immune response, or pathologic lesions. Mice that receive immunocompetent T cells, however, develop rapidly progressive severe gastritis. This model allows us to investigate separately the 1) direct effect of bacteria upon gastric epithelium in non-transferred mice, and 2) the effect of specific immune cells and cytokines in recipient mice. The current focus of the laboratory is the role of inflammatory cytokines to induction of the host immune response.
Enterohemorrhagic E. coli (EHEC)

EHEC are Shiga-toxin producing pathogenic E. coli most often of the O157 serotype. They are food-borne pathogens of humans, and cause severe hemorrhagic colitis and sometimes hemolytic-uremic syndrome (HUS), a life-threatening triad of acute renal failure, hemolysis, and thrombocytopenia. The Eaton laboratory uses a germ-free mouse model to study bacterial factors that promote renal disease and to examine the differential expression of bacterial genes in vivo.

Germ-free and gnotobiotic mice

In addition to H. pylori and EHEC studies, Dr. Eaton has established a germ-free and gnotobiotic mouse facility at the University of Michigan. This multi-user facility derives, produces, and maintains several strains of germ-free and gnotobiotic mice for investigator use. Germ-free mice are completely free of exogenous bacterial, fungal, and viral microorganisms. They can be bred and maintained indefinitely in soft-sided bubble-type isolators, or for short periods in sterile microisolator cages in a laminar flow hood. These mice are ideal for the study of host pathogen interactions in a controlled environment, and for study of the roles of normal microbiota or their absence on host physiology and disease. Mice in our facility are currently used for the study of infectious diseases such as EHEC, Campylobacter jejuni, and Vibrio cholerae, and the role of enteric microbiota in gastric and colon cancer and host immune responses

Published Articles or Reviews

Tucker, T. P., B. M. Gray, K. A. Eaton, and J. L. Merchant. 2011. Helicobacter pylori induction of the gastrin promoter through GC-rich DNA elements. Helicobacter. 15:438-448.

K. A. Eaton, J. S. Opp, B. M. Gray, I. L. Bergin, and V. B. Young. 2011. Ulcerative typhlocolitis associated with Helicobacter mastomyrinus in telomerase-deficient mice. Vet Pathol 48:713-725.

K. A. Eaton, A. Honkala, T. A. Auchtung, and R. A. Britton. 2011. Probiotic Lactobacillus reuteri ameliorates disease due to enterohemorrhagic Escherichia coli in germfree mice. Infect Immun79:185-191.

Kao, J. Y., M. Zhang, M. J. Miller, J. C. Mills, B. Wang, M. Liu, K. A. Eaton, W. Zou, B. E. Berndt, T. S. Cole, T. Takeuchi, S. Y. Owyang, and J. Luther. 2010. Helicobacter pylori Immune Escape Is Mediated by Dendritic Cell-Induced Treg Skewing and Th17 Suppression in Mice. Gastroenterology. 138:1046-1054.

K. A. Eaton, D. I. Friedman, G. J. Francis, J. S. Tyler, V. B. Young, J. Haeger, G. Abu-Ali, and T. S. Whittam. 2008. Pathogenesis of renal disease due to enterohemorrhagic Escherichia coli in germ-free mice. Infect Immun 76:3054-3063.

K. A. Eaton, S. J. Danon, S. Krakowka, and S. E. Weisbrode. 2007. A Reproducible Scoring System for Quantification of Histologic Lesions of Inflammatory Disease in Mouse Gastric Epithelium. Comp Med 57:57-65.

K. A. Eaton, L. H. Benson, J. Haeger, and B. M. Gray. 2006. Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice. Infect Immun 74:4673-4684.

K. A. Eaton, S. M. Logan, P. E. Baker, R. A. Peterson, M. A. Monteiro, and E. Altman. 2004. Helicobacter pylori with a truncated lipopolysaccharide O chain fails to induce gastritis in SCID mice injected with splenocytes from wild-type C57BL/6J mice. Infect Immun 72:3925-3931.

Wanken, A. E., T. Conway, and K. A. Eaton. 2003. The Entner-Doudoroff pathway has little effect on Helicobacter pylori colonization of mice. Infect Immun 71:2920-2923.

Peterson, R. A., 2nd, T. Hoepf, and K. A. Eaton. 2003. Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis. Comp Med 53:498-509.

K. A. Eaton, J. V. Gilbert, E. A. Joyce, A. E. Wanken, T. Thevenot, P. Baker, A. Plaut, and A. Wright. 2002. In Vivo Complementation of ureB Restores the Ability of Helicobacter pylori To Colonize.Infect Immun 70:771-778.

K. A. Eaton, M. Mefford, and T. Thevenot. 2001. The Role of T Cell Subsets and Cytokines in the Pathogenesis of Helicobacter pylori Gastritis in Mice. J Immunol 166:7456-7461.