Mary O'Riordan, Ph.D.

Frederick C Neidhardt Collegiate Professor
Professor of Microbiology and Immunology

Areas of Interest

Our laboratory explores the interaction of intracellular bacterial pathogens with their host cells. We use Staphylococcus aureus and other bacterial pathogens to explore host mechanisms that regulate infection and innate immune signaling with a focus on mammalian cellular stress circuits.

Published Articles or Reviews

Reynolds MB, Hong HS, Michmerhuizen BC, Lawrence AE, Zhang L, Knight JS, Lyssiotis CA, Abuaita BH, O'Riordan MX. Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation. Sci Adv. 2023 Feb 3;9(5):eade8701. doi: 10.1126/sciadv.ade8701. Epub 2023 Feb 3. PMID: 36735777; PMCID: PMC9897665. 

Lawrence AE, Berger RP, Hill DR, Huang S, Yadagiri VK, Bons B, Fields C, Sule GJ, Knight JS, Wobus CE, Spence JR, Young VB, O'Riordan MX, Abuaita BH. Human neutrophil IL1β directs intestinal epithelial cell extrusion during Salmonella infection. PLoS Pathog. 2022 Oct 3;18(10):e1010855. doi: 10.1371/journal.ppat.1010855. PMID: 36191054; PMCID: PMC9578578.

Abuaita BH, Sule GJ, Schultz TL, Gao F, Knight JS, O'Riordan MX. The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function. J Immunol. 2021 Jul 1;207(1):210-220. doi: 10.4049/jimmunol.2001321. Epub 2021 Jun 18. PMID: 34145058; PMCID: PMC8683563.

Lawrence AE, Abuaita BH, Berger RP, Hill DR, Huang S, Yadagiri VK, Bons B, Fields C, Wobus CE, Spence JR, Young VB, O'Riordan MX. Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System. mBio. 2021 May 18;12(3):e00399-21. doi: 10.1128/mBio.00399-21. PMID: 34006652; PMCID: PMC8262845.

Gao F, Reynolds MB, Passalacqua KD, Sexton JZ, Abuaita BH, O'Riordan MXD. The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α. Front Cell Infect Microbiol. 2021 Jan 14;10:593805. doi: 10.3389/fcimb.2020.593805. PMID: 33520735; PMCID: PMC7840702.

Abuaita BH, Schultz TL, O'Riordan MX. Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus. Cell Host Microbe. 2018 Nov 14;24(5):625-636.e5. doi: 10.1016/j.chom.2018.10.005. Epub 2018 Oct 25. PMID: 30449314; PMCID: PMC7323595.

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