Dr. Goldstein came to Michigan last year from Yale University as a physician scientist and cellular immunologist who works on aging and inflammation, specifically during acute influenza viral infection, and also in atherosclerosis. His lab also has over 15 years' experience in the transplant immunology field, in which they investigated the role of innate immunity in organ transplantation.
Dr. Goldstein's laboratory was the first to define the role of the Toll-like receptors (TLRs) in organ transplantation by showing that TLRs were required for murine skin graft rejection. He and his group also defined the functions of TLRs and downstream mediators in acute cardiac allograft rejection and in transplantation tolerance. More recently, via a proteomic screen, his lab has identified haptoglobin as a unique activator of MyD88 that enhances skin graft rejection and impairs indefinite survival of cardiac allografts. His work has been clinically translated and has led to the development of TLR inhibition strategies in solid organ transplantation.
His lab is also examining the efficacy of novel vaccines to protect aged hosts from influenza viral infection and novel pathways by which aging impairs immune regulation of allografts. They have further discovered pathways by which aging induces increased inflammation in vascular smooth muscle cells and increased macrophage apoptosis, findings that may explain how aging enhances atherosclerosis.
We are very happy to welcome Dr. Goldstein to the Department, and his research expertise and teaching interests will add to the spectrum of research interactions available to our faculty, postdoctoral fellows and graduate students.