February 9, 2021

Good news and Publications


February 9, 2021

New Publications from M&I- Congrats to all the authors!


Human Respiratory Syncytial Virus Infection in a Human T Cell Line Is Hampered at Multiple Steps.

de Souza Cardoso R, Viana RMM, Vitti BC, Coelho ACL, de Jesus BLS, de Paula Souza J, Pontelli MC, Murakami T, Ventura AM, Ono A, Arruda E.

Viruses. 2021 Feb 2;13(2):231. doi: 10.3390/v13020231.

PMID: 33540662


The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α.

Gao F, Reynolds MB, Passalacqua KD, Sexton JZ, Abuaita BH, O'Riordan MXD.

Front Cell Infect Microbiol. 2021 Jan 14;10:593805. doi: 10.3389/fcimb.2020.593805. eCollection 2020.

PMID: 33520735 Free PMC article.


Degradation of complex arabinoxylans by human colonic Bacteroidetes.

Pereira GV, Abdel-Hamid AM, Dutta S, D'Alessandro-Gabazza CN, Wefers D, Farris JA, Bajaj S, Wawrzak Z, Atomi H, Mackie RI, Gabazza EC, Shukla D, Koropatkin NM, Cann I.

Nat Commun. 2021 Jan 19;12(1):459. doi: 10.1038/s41467-020-20737-5.

PMID: 33469030 Free PMC article.

Variations in MHC class I antigen presentation and immunopeptidome selection pathways.

Zaitoua AJ, Kaur A, Raghavan M.

F1000Res. 2020 Sep 28;9:F1000 Faculty Rev-1177. doi: 10.12688/f1000research.26935.1. eCollection 2020.

PMID: 33014341 Free PMC article. Review.

Biological subphenotypes of acute respiratory distress syndrome may not reflect differences in alveolar inflammation.

Heijnen NFL, Hagens LA, Smit MR, Schultz MJ, van der Poll T, Schnabel RM, van der Horst ICC, Dickson RP, Bergmans DCJJ, Bos LDJ; BASIC consortium.

Physiol Rep. 2021 Feb;9(3):e14693. doi: 10.14814/phy2.14693.

PMID: 33547768

Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.

Opron K, Begley LA, Erb-Downward JR, Freeman C, Madapoosi S, Alexis NE, Barjaktarevic I, Graham Barr R, Bleecker ER, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper DJ, Doerschuk CM, Dransfield MT, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Krishnan J, O'Neal WK, Ortega VE, Paine R 3rd, Peters SP, Michael Wells J, Woodruff PG, Martinez FJ, Curtis JL, Huffnagle GB, Huang YJ.

NPJ Biofilms Microbiomes. 2021 Feb 5;7(1):14. doi: 10.1038/s41522-021-00185-9.

PMID: 33547327


Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling.

Song J, Frieler RA, Whitesall SE, Chung Y, Vigil TM, Muir LA, Ma J, Brombacher F, Goonewardena SN, Lumeng CN, Goldstein DR, Mortensen RM.

Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H323-H337. doi: 10.1152/ajpheart.00251.2020. Epub 2020 Nov 8.

PMID: 33164548


Now out in Pub Med

Effects of tumor necrosis factor on viral replication and pulmonary inflammation during acute mouse adenovirus type 1 respiratory infection.

Pant K, Chandrasekaran A, Chang CJ, Vageesh A, Popkov AJ, Weinberg JB.

Virology. 2020 Aug;547:12-19. doi: 10.1016/j.virol.2020.05.004. Epub 2020 May 23.

PMID: 32560900


The Bacterial Connection between the Oral Cavity and the Gut Diseases.

Kitamoto S, Nagao-Kitamoto H, Hein R, Schmidt TM, Kamada N.

J Dent Res. 2020 Aug;99(9):1021-1029. doi: 10.1177/0022034520924633. Epub 2020 May 28.

PMID: 32464078 Review. 


January 19, 2021


·       M&I is pleased to congratulate Dr. Ajay Kumar on his promotion to Research Investigator. Welcome to the faculty!


·       Laura Mike will be opening her own lab at the University of Toledo in July in the Department of Medical Microbiology and Immunology in the College of Medicine and Life Sciences. Congrats! You’ll be close enough to collaborate with us still!


Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin.

Mohan HM, Yang B, Dean NA, Raghavan M.

J Biol Chem. 2020 Dec 4;295(49):16754-16772. doi: 10.1074/jbc.RA120.014372.

PMID: 33453909


TonB-Dependent Transporters in the Bacteroidetes: Unique Domain Structures and Potential Functions.

Pollet RM, Martin LM, Koropatkin NM.

Mol Microbiol. 2021 Jan 15. doi: 10.1111/mmi.14683. Online ahead of print.

PMID: 33448497 Review.

Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.

Covés-Datson EM, King SR, Legendre M, Swanson MD, Gupta A, Claes S, Meagher JL, Boonen A, Zhang L, Kalveram B, Raglow Z, Freiberg AN, Prichard M, Stuckey JA, Schols D, Markovitz DM.

Sci Rep. 2021 Jan 12;11(1):656. doi: 10.1038/s41598-020-80577-7.

PMID: 33436903 Free PMC article.

Toxoplasma gondii: Bradyzoite Differentiation In Vitro and In Vivo.

Mayoral J, Di Cristina M, Carruthers VB, Weiss LM.

Methods Mol Biol. 2020;2071:269-282. doi: 10.1007/978-1-4939-9857-9_15.

PMID: 31758458 Free PMC article.

PCR Screening of Toxoplasma gondii SingleClones Directly from 96-Well Plates Without DNA Purification.

Piro F, Carruthers VB, Di Cristina M.

Methods Mol Biol. 2020;2071:117-123. doi: 10.1007/978-1-4939-9857-9_6.

PMID: 31758449



Lessons learned from the prenatal microbiome controversy.

Blaser MJ, Devkota S, McCoy KD, Relman DA, Yassour M, Young VB.

Microbiome. 2021 Jan 12;9(1):8. doi: 10.1186/s40168-020-00946-2.

PMID: 33436098 Free PMC article.

Turning the Lungs Inside Out: The Intersecting Microbiomes of the Lungs and the Built Environment.

Combs MP, Dickson RP.

Am J Respir Crit Care Med. 2020 Dec 15;202(12):1618-1620. doi: 10.1164/rccm.202007-2973ED.

PMID: 32822203 Free PMC article. No abstract available.

Aging Dampens the Intestinal Innate Immune Response during Severe Clostridioides difficile Infection and Is Associated with Altered Cytokine Levels and Granulocyte Mobilization.

Abernathy-Close L, Dieterle MG, Vendrov KC, Bergin IL, Rao K, Young VB.

Infect Immun. 2020 May 20;88(6):e00960-19. doi: 10.1128/IAI.00960-19. Print 2020 May 20.

PMID: 32284366 Free PMC article.


Genetic Variants of SARS-CoV-2-What Do They Mean?

Lauring AS, Hodcroft EB.

JAMA. 2021 Jan 6. doi: 10.1001/jama.2020.27124. Online ahead of print.

PMID: 33404586 No abstract available.

Genomic Epidemiology of MRSA During Incarceration at a Large Inner-City Jail.

Popovich KJ, Thiede SN, Zawitz C, Aroutcheva A, Payne D, Janda W, Schoeny M, Green SJ, Snitkin ES, Weinstein RA.

Clin Infect Dis. 2021 Jan 4:ciaa1937. doi: 10.1093/cid/ciaa1937. Online ahead of print.

PMID: 33395473

HLA tapasin independence: broader peptide repertoire and HIV control.

Bashirova AA, Viard M, Naranbhai V, Grifoni A, Garcia-Beltran W, Akdag M, Yuki Y, Gao X, O'hUigin C, Raghavan M, Wolinsky S, Bream JH, Duggal P, Martinson J, Michael NL, Kirk GD, Buchbinder SP, Haas D, Goedert JJ, Deeks SG, Fellay J, Walker B, Goulder P, Cresswell P, Elliott T, Sette A, Carlson J, Carrington M.

Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28232-28238. doi: 10.1073/pnas.2013554117. Epub 2020 Oct 23.

PMID: 33097667 Free PMC article.

Performic Acid Disinfection of Municipal Secondary Effluent Wastewater: Inactivation of Murine Norovirus, Fecal Coliforms, and Enterococci.

Maffettone R, Manoli K, Santoro D, Passalacqua KD, Wobus CE, Sarathy S.

Environ Sci Technol. 2020 Oct 6;54(19):12761-12770. doi: 10.1021/acs.est.0c05144. Epub 2020 Sep 8.

PMID: 32835477

The pneumococcal social network.

Aggarwal SD, Yesilkaya H, Dawid S, Hiller NL.

PLoS Pathog. 2020 Oct 29;16(10):e1008931. doi: 10.1371/journal.ppat.1008931. eCollection 2020 Oct.

PMID: 33119698 Free PMC article. Review.


·       CONGRATULATIONS to Oveta Fuller who has been named in the listing of 1000 Inspiring Black Scientists. This very impressive group includes many UM alumni. See the full list here.


·       Stop by the M&I mailroom to pick up a copy of “equilibrium,” a Mi-Sci writers magazine including an article by our own graduate student, Jenn Baker.  There is even a bonus baby picture.  Her article is called “No Lab Coat Required.” It is a lovely remembrance of how her grandmother influenced her identity as a scientist and it has a few key pieces of advice you don’t want to miss. You can check it out online here.


Research News


o   Daniel Goldstein on his recently awarded R35 on mitophagy acute respiratory viral infections and vascular inflammation

o   Adam Lauring who was awarded a Fast Grant to support his work in sequencing the coronavirus strains in circulation. Did you know that Adam’s lab has already sequenced 1300 whole genomes which is 2.5% of all sequences in the U.S.!  This is important work to identify new lineages and also to detect potential problems with PCR detection!  Adam was also interviewed by JAMA on Understanding SARS-CoV-2 Genetic Variants. You can hear that 41 minute interview here.



SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease.

Menon R, Otto EA, Sealfon R, Nair V, Wong AK, Theesfeld CL, Chen X, Wang Y, Boppana AS, Luo J, Yang Y, Kasson PM, Schaub JA, Berthier CC, Eddy S, Lienczewski CC, Godfrey B, Dagenais SL, Sohaney R, Hartman J, Fermin D, Subramanian L, Looker HC, Harder JL, Mariani LH, Hodgin JB, Sexton JZ, Wobus CE, Naik AS, Nelson RG, Troyanskaya OG, Kretzler M.

Kidney Int. 2020 Dec;98(6):1502-1518. doi: 10.1016/j.kint.2020.09.015. Epub 2020 Oct 8.

PMID: 33038424 Free PMC article.

ER stress increases store-operated Ca2+ entry (SOCE) and augments basal insulin secretion in pancreatic beta cells.

Zhang IX, Ren J, Vadrevu S, Raghavan M, Satin LS.

J Biol Chem. 2020 Apr 24;295(17):5685-5700. doi: 10.1074/jbc.RA120.012721. Epub 2020 Mar 16.

PMID: 32179650

Modeling Adaptive Resistance of KRAS Mutant Colorectal Cancer to MAPK Pathway Inhibitors with a Three-Dimensional Tumor Model.

Shahi Thakuri P, Lamichhane A, Singh S, Gupta M, Luker GD, Tavana H.

ACS Pharmacol Transl Sci. 2020 Oct 9;3(6):1176-1187. doi: 10.1021/acsptsci.0c00115. eCollection 2020 Dec 11.

PMID: 33344895


Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation.

Evans S, Butler JR, Mattila JT, Kirschner DE.

PLoS Comput Biol. 2020 Dec 28;16(12):e1008520. doi: 10.1371/journal.pcbi.1008520. Online ahead of print.

PMID: 33370784


The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

Weinberg F, Dickson RP, Nagrath D, Ramnath N.

Cancers (Basel). 2020 Dec 22;13(1):E13. doi: 10.3390/cancers13010013.

PMID: 33375062 Review.


Racial Bias in Pulse Oximetry Measurement.

Sjoding MW, Dickson RP, Iwashyna TJ, Gay SE, Valley TS.

N Engl J Med. 2020 Dec 17;383(25):2477-2478. doi: 10.1056/NEJMc2029240.

PMID: 33326721 No abstract available.



RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice

Phil King and his collaborators are featured on the cover of December’s Development





Beth Moore was named the 2021 recipient of the Elizabeth A. Rich, MD Award within the American Thoracic Society. 

Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease.

Rule CS, Park YJ, Delarosa JR, Turley S, Hol WGJ, McColm S, Gura C, DiMaio F, Korotkov KV, Sandkvist M.

mSphere. 2020 Dec 16;5(6):e01125-20. doi: 10.1128/mSphere.01125-20.

PMID: 33328352

Imaging living obligate anaerobic bacteria with bilin-binding fluorescent proteins.

Chia HE, Zuo T, Koropatkin NM, Marsh ENG, Biteen JS.

Curr Res Microb Sci. 2020 Sep;1:1-6. doi: 10.1016/j.crmicr.2020.04.001. Epub 2020 May 11.

PMID: 33313576 Free PMC article.

Identification of a unique temporal signature in blood and BAL associated with IPF progression.

Norman KC, O'Dwyer DN, Salisbury ML, DiLillo KM, Lama VN, Xia M, Gurczynski SJ, White ES, Flaherty KR, Martinez FJ, Murray S, Moore BB, Arnold KB.

Sci Rep. 2020 Jul 21;10(1):12049. doi: 10.1038/s41598-020-67956-w.

PMID: 32694604 Free PMC article.


Inter-Kingdom Communication and Regulation of Mucosal Immunity by the Microbiome.

Ethridge AD, Bazzi MH, Lukacs NW, Huffnagle GB.

J Infect Dis. 2020 Dec 17:jiaa748. doi: 10.1093/infdis/jiaa748. Online ahead of print.

PMID: 33330908


Racial Bias in Pulse Oximetry Measurement.

Sjoding MW, Dickson RP, Iwashyna TJ, Gay SE, Valley TS.

N Engl J Med. 2020 Dec 17;383(25):2477-2478. doi: 10.1056/NEJMc2029240.

PMID: 33326721 No abstract available.


Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis.

Kimball AS, Obi AT, Luke CE, Dowling AR, Cai Q, Adili R, Jankowski H, Schaller M, Holinstadt M, Jaffer FA, Kunkel SL, Gallagher KA, Henke PK.

Thromb Haemost. 2020 Feb;120(2):289-299. doi: 10.1055/s-0039-3400959. Epub 2019 Dec 30.

PMID: 31887775 Free PMC article.