Cell Biology of Infection

The study of host-pathogen interactions reveals information about disease but also sheds light on fundamental mechanisms of normal cellular function. Using quantitative live cell imaging and other approaches, our research on the bacterial and eukaryotic pathogens, Legionella, Listeria, Salmonella, and Toxoplasma show that these microbes take advantage of the host cell niche by manipulating cellular trafficking pathways. Studies also focus on mechanisms by which intracellular pathogens exploit infected host cells to facilitate cell invasion, acquire nutrients, and regulate differentiation. Infection and other pathological conditions trigger host signaling that result in anti-microbial responses and release of inflammatory mediators. Host regulators of innate immune responses to infection are currently being explored. In addition, chemical signals, such as calcium and NADPH, are being studied in live cells and tissues to determine the effects of biochemical changes on the immune response. Finally, eukaryotic cell cycle regulation and how human disease related proteins are modified during the cell cycle are being investigated.

Faculty researching Cell Biology of Infection

Vernon B. Carruthers, Ph.D.

Associate Chair, Department of Microbiology and Immunology
Professor of Microbiology and Immunology
734-763-2081

Bethany B. Moore, Ph.D.

Chair, Department of Microbiology and Immunology
Nancy Williams Walls Professor of Microbiology and Immunology
Professor of Microbiology and Immunology
Professor of Internal Medicine
734-936-0854

Mary O'Riordan, Ph.D.

Frederick C Neidhardt Collegiate Professor
Professor of Microbiology and Immunology
734-615-4289

Michele Swanson, Ph.D.

Professor of Microbiology and Immunology
Director of Postdoctoral Studies, Medical School
734-647-7295
Jason Weinberg, MD

Jason Weinberg, M.D.

James L Wilson M. D. Research Professor of Pediatrics
Associate Professor of Pediatrics
Associate Professor of Microbiology and Immunology
Pediatric Infectious Diseases and Section Head, Infectious Diseases
734-764-6265