Teresa O'Meara, PhD

Assistant Professor

5608B Medical Science Building II

734-647-1853

Areas of Interest

The O'Meara lab is interested in how organisms can sense and respond to the environment, with a particular focus on how pathogens adapt to the stresses of a human host. We want to understand how fungal pathogens are able to cause disease in humans. This includes asking questions about host-pathogen interactions and the evolution and selective pressures driving pathogenesis. We use functional genomics and genetic approaches to answer these questions.

Published Articles or Reviews

Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen. O’Meara TR, O’Meara MJ, Polvi EJ, Pourhaghighi MR, Liston SD, Lin Z-Y, Veri AO, Emili A, Gingras A-C, Cowen LE. PLoS Biology Jul 8;17(7):e3000358. 2019. PMID: 31283755

mSphere of Influence: Start with an Interesting Biological Phenomenon. O’Meara T. mSphere. Jun 19;4(3). 2019 PMID: 31217302 (Review)

Insights into the host-pathogen interaction: C. albicans manipulation of macrophage pyroptosis. O’Meara TR and Cowen LE. Microbial Cell 12;5(12):566-568. 2018 PMID: 30533421 (Review)

High-throughput screening identifies genes required for fungal induction of macrophage pyroptosis. O’Meara TR, Duah K, Guo CX, Maxson ME, Gaudet R, Koselny K, Wellington M, Powers ME, MacAlpine J, O’Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen S, Cowen LE. MBio. 21;9(4), 2018 PMID: 30131363

The Hsp90 chaperone network modulates Candida virulence traits. O’Meara TR, Robbins N, and and Cowen LE. Trends in Microbiology, 25(10):809-81,9 2017. PMID: 28549824 (Review)

Mapping the Hsp90 genetic network reveals ergosterol biosynthesis and phosphatidylinositol-4-kinase signaling as core circuitry governing cellular stress. O'Meara TR, Veri AO*, Polvi EJ*, Li X*, Valaei SF, Diezmann S, Cowen LE. PLoS Genetics 12(6):e1006142, 2016. PMID: 27341673 (*contributed equally) (Highlighted in F1000)

Global analysis of fungal morphology exposes mechanisms of host cell escape. O’Meara TR*, Veri AO*, Ketela T, Jiang B, Roemer T, Cowen LE. Nature Communications 6:6741, 2015. PMID: 25824284 (*contributed equally)

Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence. O’Meara TR and Cowen LE. Cellular Microbiology 2014. PMID: 24438186 (Review, Highlighted in F1000)

Web Sites