Vincent Young, M.D., Ph.D.

Professor
734-764-2237

Appointments

Department of Internal Medicine/Infectious Diseases Division
Department of Microbiology and Immunology

Areas of Interest

Microbial ecology of gastrointestinal bacterial infections

Research in the Young lab is directed at understanding the role of bacteria that inhabit the gastrointestinal tract and how they influence the health status of the host. To this end, we study the role of what would traditionally be considered “pathogenic bacteria” in gastrointestinal illness, with a particular emphasis on Clostridium difficile . In addition, we also examine how the population structure of the indigenous GI microbiota can influence the host-pathogen interaction and how changes in the community structure of the indigenous microbiota itself can lead to pathogenic states. This research is being conducted both with material from human subjects as well as animal models of disease.

Published Articles or Reviews

1. Koenigsknecht, M. J., C. M. Theriot, I. L. Bergin, C. A. Schumacher, P. D. Schloss, and V. B. Young. 2015. Dynamics and Establishment of Clostridium difficile Infection in the Murine Gastrointestinal Tract. Infect Immun 83:934-41 http://www.ncbi.nlm.nih.gov/pubmed/25534943

2. Leslie, J. L., S. Huang, J. S. Opp, M. S. Nagy, M. Kobayashi, V. B. Young, and J. R. Spence. 2015. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Infect Immun 83:138-45. PMCID:PMC4288864 
http://www.ncbi.nlm.nih.gov/pubmed/25312952

3. Leslie, J. L., and V. B. Young. 2015. The rest of the story: the microbiome and gastrointestinal infections. Curr Opin Microbiol 23C:121-125. PMCID:PMC4324160 
http://www.ncbi.nlm.nih.gov/pubmed/25461582

4. Leslie, J. L., and V. B. Young. 2015. A whole new ball game: Stem cell-derived epithelia in the study of host-microbe interactions.Anaerobe 
http://www.ncbi.nlm.nih.gov/pubmed/26549696

5. Rao, K., and V. B. Young. 2015. Fecal Microbiota Transplantation for the Management of Clostridium difficile Infection. Infect Dis Clin North Am 29:109-122. PMCID:PMC4328137 
http://www.ncbi.nlm.nih.gov/pubmed/25677705

6. Seekatz, A. M., J. Aas, C. E. Gessert, T. A. Rubin, D. M. Saman, J. S. Bakken, and V. B. Young. 2014. Recovery of the Gut Microbiome following Fecal Microbiota Transplantation. MBio 5
http://www.ncbi.nlm.nih.gov/pubmed/24939885

7. Seekatz, A. M., C. M. Theriot, C. T. Molloy, K. L. Wozniak, I. L. Bergin, and V. B. Young. 2015. Fecal Microbiota Transplantation Eliminates Clostridium difficile in a Murine Model of Relapsing Disease. Infect Immun 83:3838-46. PMCID:PMCPMC4567621 
http://www.ncbi.nlm.nih.gov/pubmed/26169276

8. Seekatz, A. M., and V. B. Young. 2014. Clostridium difficile and the microbiota. J Clin Invest:1-8 
http://www.ncbi.nlm.nih.gov/pubmed/25036699

9. Shreiner, A. B., J. Y. Kao, and V. B. Young. 2015. The gut microbiome in health and in disease. Curr Opin Gastroenterol 31:69-75. PMCID:PMC4290017 
http://www.ncbi.nlm.nih.gov/pubmed/25394236

10. Theriot, C. M., M. J. Koenigsknecht, P. E. Carlson, Jr., G. E. Hatton, A. M. Nelson, B. Li, G. B. Huffnagle, Z. L. J, and V. B. Young. 2014. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat Commun 5:3114. PMCID:PMC3950275 
http://www.ncbi.nlm.nih.gov/pubmed/24445449

11. Theriot, C. M., and V. B. Young. 2015. Interactions Between the Gastrointestinal Microbiome and Clostridium difficile. Annu Rev Microbiol 69:44561 
http://www.ncbi.nlm.nih.gov/pubmed/26488281

12. Theriot, C. M., and V. B. Young. 2014. Microbial and metabolic interactions between the gastrointestinal tract and Clostridium difficile infection. Gut Microbes 5:86-95. PMCID:PMC4049944 
http://www.ncbi.nlm.nih.gov/pubmed/24335555

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