Evaluating how fat affects peripheral nerve function
Dr. Rumora is interested in understanding how different types of dietary fat impact the peripheral nervous system so that treatments to prevent the onset and progression of diabetic neuropathy can be developed. Using cultured cells and animal models of neuropathy, Dr. Rumora recently identified a differential effect of saturated and unsaturated fats on the neurons involved in the progression. Interestingly, she found that one type of unsaturated fat can reverse the progression of neuropathy and restore nerve function, and she is now evaluating the underlying molecular changes facilitated by this unsaturated fat that restore nerve function. Specifically, she is using advanced imaging technologies to understand how fat affects the ability of mitochondria, the energy producing powerhouse of the cell, to travel along the length of the neurons. This work will provide important insights into how nerves are damaged, as well as offer insights into potential dietary approaches to maintain nerve health.
- BA, Biochemistry, Mount Holyoke College, 2007
- PhD, Biochemistry, University of Vermont, 2014
Honors & Awards
- K99/R00 Pathway to Independence Award, National Institutes of Health
- T32 Trainee, University of Michigan Multidisciplinary Postdoctoral Training Program in Basic Diabetes Research, National Institutes of Health
- Principal Investigator, F32 Ruth L. Kirschstein National Research Service Award, National Institutes of Health
- Young Investigator Oral Presentation Award, NeuroDiab
- Travel awards, American Neurological Association and Peripheral Nerve Society
PNRD Research on Diabetic Neuropathy chosen as 6 “Highlights of the Meeting,” out of submissions by over 800 of the nation’s top neurologists at the American Neurological Association’s Annual meeting.