Eva Feldman, MD, PhD

Dr. Feldman is one of the world’s leading authorities on neurodegenerative disease. Currently, she serves as the University of Michigan James W. Albers Distinguished University Professor and the Russell N. DeJong Professor of Neurology at Michigan Medicine. She is also the Director of the NeuroNetwork for Emerging Therapies and ALS Center of Excellence at Michigan Medicine.

Feldman has made contributions to biomedical research and clinical care in many critical areas of neurodegenerative disease. Her primary focus has been on amyotrophic lateral sclerosis (ALS), Alzheimer's disease, cognitive decline, and the neurologic complications of diabetes and obesity, as well as how environmental toxins affect the nervous system. She also has conducted pioneering research on developing stem cell therapies to treat these diseases.

Feldman is annually listed in Best Doctors in America, is a member of the Association of American Physicians and the National Academy of Medicine, and is a Fellow of the American Association for the Advancement of Science. Feldman has authored over 530 articles and 74 book chapters (Google Scholar h-index = 117) with >55,000 citations. She has been continuously NIH-funded since 1989 and has received numerous awards and honors throughout her remarkable career.

• BA, Biology and Chemistry, Earlham College, 73
• MS, Zoology, University of Notre Dame, 75
• PhD, Neuroscience, University of Michigan, 79
• MD, Medicine, University of Michigan, 83
• Residency, Neurology, Johns Hopkins Hospital, 87
• Chief Resident, Neurology, Johns Hopkins Hospital, 86-87
• Fellowship, EMG/Physical Medicine & Rehabilitation, University of Michigan Health System, 88

• Annually listed in Castle Connolly's Best Doctors in America 
• National Academy of Medicine (NAM) Council (governing and oversight)
• University of Michigan's Distinguished Professorship, 2022
• The American Clinical Neurophysiology Society Robert S. Schwab Award (2022)—the first woman to receive the award in its 25-year history
• American Neurological Association’s Raymond D. Adams Lectureship Award (2021)
• American Association for the Advancement of Science (AAAS) Fellow (2020)
• Michigan Medicine Alumni Society Distinguished Achievement Award (2019) and Early Career Distinguished Achievement Award (2001)—the only alumnus to receive both awards
• Peripheral Nerve Society Alan J. Gebhart Prize for Excellence in Peripheral Nerve Research (2019)
• Marquis Who’s Who in the World Lifetime Award (2018)
• Gerald D. Aurbach Award for Outstanding Translational Research, Endocrine Society (2017)
• Castle Connolly National Physician of the Year Award for Clinical Excellence (2016)
• Society for Neuroscience Bernice Grafstein Award for Outstanding Accomplishments in Mentoring (2016)
• National Academy of Medicine of the National Academies of Sciences, Engineering and Medicine, Member (2014)
• American Diabetes Association Lifetime Achievement Award (2006)
• Juvenile Diabetes Research Foundation Mary Jane Kugel Award (2005, 2003)

• Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ, Sobue G. Amyotrophic lateral sclerosis. Lancet. 2022 Oct 15;400(10360):1363-1380. doi: 10.1016/S0140-6736(22)01272-7. Epub 2022 Sep 15. PMID: 36116464; PMCID: PMC10089700.
• Dou J, Bakulski K, Guo K, Hur J, Zhao L, Saez-Atienzar S, Stark A, Chia R, García-Redondo A, Rojas-Garcia R, Vázquez Costa JF, Fernandez Santiago R, Bandres-Ciga S, Gómez-Garre P, Periñán MT, Mir P, Pérez-Tur J, Cardona F, Menendez-Gonzalez M, Riancho J, Borrego-Hernández D, Galán-Dávila L, Infante Ceberio J, Pastor P, Paradas C, Dols-Icardo O, Traynor BJ, Feldman EL, Goutman SA; Spanish Neurological Consortium. Cumulative Genetic Score and C9orf72 Repeat Status Independently Contribute to Amyotrophic Lateral Sclerosis Risk in 2 Case-Control Studies. Neurol Genet. 2023 May 31;9(4):e200079. doi: 10.1212/NXG.0000000000200079. Erratum in: Neurol Genet. 2023 Jul 25;9(5):e200095. PMID: 37293291; PMCID: PMC10245939.
• Benatar M, Goutman SA, Staats KA, , Weisskopf M, Talbott E, Dave KD, Thakur NM, Al-Chalabi A. A roadmap to ALS prevention: strategies and priorities. J Neurol Neurosurg Psychiatry. 2023 May;94(5):399-402. doi: 10.1136/jnnp-2022-330473. Epub 2023 Jan 23. PMID: 36690429; PMCID: PMC10176353.
• Murdock BJ, Famie JP, Piecuch CE, Raue KD, Mendelson FE, Pieroni CH, Iniguez SD, Zhao L, Goutman SA, Feldman EL. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight. 6(11):e147129, 2021. PMC8262328.
• Murdock BJ, Goutman SA, Boss J, Kim S, Feldman EL. Amyotrophic Lateral Sclerosis Survival Associates With Neutrophils in a Sex-specific Manner. Neurol Neuroimmunol Neuroinflamm. 2021 Feb 2;8(2):e953. PMC8057067
• Figueroa-Romero C, Monteagudo A, Murdock BJ, Famie JP, Webber-Davis IF, Piecuch CE, Teener SJ, Pacut C, Goutman SA, Feldman EL. Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis. Front Immunol. 2022 Feb 7;13:773288. PMC8859451
• Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL. Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis. Lancet Neurol. 2022 May;21(5):465-479. PMC9513754
• Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL. Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. Lancet Neurol. 2022 May;21(5):480-493. PMC9513753
• Goutman SA, Boss J, Godwin C, Mukherjee B, Feldman EL, Batterman SA. Occupational history associates with ALS survival and onset segment. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Oct 3:1-11.
• Hur J, Paez-Colasante X, Figueroa-Romero C, Lo TW, Barmada SJ, Paulsen M, Ljungman M, Alakwaa FM, Savelieff MG, Goutman SA, Feldman EL. miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis. Hum Mol Genet. 2022 Oct 11:ddac250.
• Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ, Sobue G. Amyotrophic lateral sclerosis. Lancet. 2022 Oct 15;400(10360):1363-1380.
• Goutman SA, Guo K, Savelieff MG, Patterson A, Sakowski SA, Habra H, Karnovsky A, Hur J, Feldman EL. Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts. Brain. 2022 Dec 19;145(12):4425-4439. PMC9762943

• Tadesse T, Gearing M, Senitzer D, Saxe D, Brat DJ, Bray R, Genel H, Hill C, Boulis N, Riley J, Feldman E, Johe K, Hazel T, Polak M, Bordeau J, Federici T, Glass JD. Analysis of graft survival in a trial of stem cell transplant in ALS. Ann Clin Transl Neurol. 1(11):900-8, 2014. PMC4265061
• Glass JD, Hertzberg VS, Boulis NM, Riley J, Federici T, Polak M, Bordeau J, Fournier C, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges LF, Rutkove SB, Duell J, Patil PG, Goutman SA, Feldman EL. Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials. Neurology. 87(4):392-400, 2016. PMC4977116
• Goutman SA, Brown MB, Glass JD, Boulis NM, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges L, Patil PG, Sakowski SA, Feldman EL. Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS. Ann Clin Transl Neurol. 5(6), 730-740, 2018. PMC5989736
• Goutman SA, Savelieff MG, Sakowski SA, Feldman EL. Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials. Exp Opin Investig Drugs. 28(6):525-543, 2019. PMC6697143

• McGinley LM, Sims E, Lunn JS, Kashlan ON, Chen KS, Bruno ES, Pacut CM, Hazel T, Johe K, Sakowski SA, Feldman EL. Human cortical neural stem cells expressing insulin-like growth factor-I: A novel cellular therapy for Alzheimer’s disease. Stem Cells Transl Med. 2016 Mar;5(3):379-91. PMC4807660
• McGinley LM, Kashlan ON, Bruno ES, Chen KS, Hayes JM, Kashlan SR, Raykin J, Johe K, Murphy GG, Feldman EL. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep, 8(1), 14776, 2018. PMC6170460
• McGinley LM, Willsey MS, Kashlan ON, Chen KS, Hayes JM, Bergin IL, Mason SN, Stebbins AW, Kwentus JF, Pacut C, Kollmer J, Sakowski SA, Bell CB 3rd, Chestek CA, Murphy GG, Patil PG, Feldman EL. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2021 Jan;10(1):83-97. PMC7780819
• McGinley LM, Chen KS, Mason SN, Rigan DM, Kwentus JF, Hayes JM, Glass ED, Reynolds EL, Murphy GG, Feldman EL. Monoclonal antibody-mediated immunosuppression enables long-term survival of transplanted human neural stem cells in mouse brain. Clin Transl Med. 2022 Sep;12(9):e1046. PMC9471059

• Henn RE, Guo K, Elzinga SE, Noureldein MH, Mendelson FE, Hayes JM, Rigan DM, Savelieff MG, Hur J, Feldman EL. Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity. iScience. 2023 Feb 8;26(3):106164. doi: 10.1016/j.isci.2023.106164. PMID: 36915697; PMCID: PMC10006681.
• Muñiz AJ, Topal T, Brooks MD, Sze A, Kim DH, Jordahl J, Nguyen J, Krebsbach PH, Savelieff MG, Feldman EL, Lahann J. Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells. Ann Clin Transl Neurol. 2023 Jul;10(7):1239-1253. doi: 10.1002/acn3.51820. Epub 2023 Jun 7. PMID: 37283238; PMCID: PMC10351667.
• Henn RE, Noureldein MH, Elzinga SE, Kim B, Savelieff MG, Feldman EL. Glial-neuron crosstalk in health and disease: A focus on metabolism, obesity, and cognitive impairment. Neurobiol Dis. 2022 Aug;170:105766.
• Elzinga SE, Henn R, Murdock BJ, Kim B, Hayes JM, Mendelson F, Webber-Davis I, Teener S, Pacut C, Lentz SI, Feldman EL. cGAS/STING and innate brain inflammation following acute high-fat feeding. Front Immunol. 2022 Sep 29;13:1012594. PMC9556783
• Savelieff MG, Chen KS, Elzinga SE, Feldman EL. Diabetes and dementia: Clinical perspective, innovation, knowledge gaps. J Diabetes Complications. 2022 Nov;36(11):108333.
• Henn RE, Elzinga SE, Glass E, Parent R, Guo K, Allouch AA, Mendelson FE, Hayes J, Webber-Davis I, Murphy GG, Hur J, Feldman EL. Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice. Immun Ageing. 2022 Dec 22;19(1):67. PMC9773607

• Guo K, Figueroa-Romero C, Noureldein M, Hinder LM, Sakowski SA, Rumora AE, Petit H, Savelieff MG, Hur J, Feldman EL. Gut microbiota in a mouse model of obesity and peripheral neuropathy associated with plasma and nerve lipidomics and nerve transcriptomics. Microbiome. 2023 Mar 15;11(1):52. doi: 10.1186/s40168-022-01436-3. PMID: 36922895; PMCID: PMC10015923.
• Eid SA, Rumora AE, Beirowski B, Bennett DL, Hur J, Savelieff MG, Feldman EL. New perspectives in diabetic neuropathy. Neuron. 2023 Sep 6;111(17):2623-2641. doi: 10.1016/j.neuron.2023.05.003. Epub 2023 May 31. PMID: 37263266.
• Eid SA, Noureldein M, Kim B, Hinder LM, Mendelson FE, Hayes JM, Hur J, Feldman EL. Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination. J Neurochem. 2023 Jul;166(2):367-388. doi: 10.1111/jnc.15877. Epub 2023 Jun 16. PMID: 37328915.
• Reynolds EL, Watanabe M, Banerjee M, Chant E, Villegas-Umana E, Elafros MA, Gardner TW, Pop-Busui R, Pennathur S, Feldman EL, Callaghan BC. The effect of surgical weight loss on diabetes complications in individuals with class II/III obesity. Diabetologia. 2023 Jul;66(7):1192-1207. doi: 10.1007/s00125-023-05899-3. Epub 2023 Mar 14. PMID: 36917280; PMCID: PMC10011764.
• Bjornstad P, Dart A, Donaghue KC, Dost A, Feldman EL, Tan GS, Wadwa RP, Zabeen B, Marcovecchio ML. ISPAD Clinical Practice Consensus Guidelines 2022: Microvascular and macrovascular complications in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1432-1450. doi: 10.1111/pedi.13444. PMID: 36537531.
• Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic neuropathy: A position statement by the American Diabetes Association. Diabetes Care, 40(1), 136-154, 2017. PMC6977405
• Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V. Diabetic neuropathy. Nat Rev Dis Primers. 2019 Jun 13;5(1):42. PMC7096070
• Sajic M, Rumora AE, Kanhai AA, Dentoni G, Varatharajah S, Casey C, Brown RDR, Peters F, Hinder LM, Savelieff MG, Feldman EL, Smith KJ. High Dietary Fat Consumption Impairs Axonal Mitochondrial Function In Vivo. J Neurosci. 41(19):4321-4334, 2021. PMC8143198
• Eid SA, Feldman EL. Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy. Dis Model Mech. 14(11):dmm049337, 2021. PMC8592018
• Reynolds EL, Akinci G, Banerjee M, Looker HC, Patterson A, Nelson RG, Feldman EL, Callaghan BC. The determinants of complication trajectories in American Indians with type 2 diabetes. JCI Insight. 6(10):e146849, 2021. PMC8262294
• Callaghan BC, Reynolds EL, Banerjee M, Akinci G, Chant E, Villegas-Umana E, Rothberg AE, Burant CF, Feldman EL. Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology. Obesity (Silver Spring). 29(12):2108-2118, 2021. PMC8612943
• Guo K, Savelieff MG, Rumora AE, Alakwaa FM, Callaghan BC, Hur J, Feldman EL. Plasma Metabolomics and Lipidomics Differentiate Obese Individuals by Peripheral Neuropathy Status. J Clin Endocrinol Metab. 2022 Mar 24;107(4):1091-1109. PMC8947234
• Afshinnia F, Reynolds EL, Rajendiran TM, Soni T, Byun J, Savelieff MG, Looker HC, Nelson RG, Michailidis G, Callaghan BC, Pennathur S, Feldman EL. Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes. Ann Clin Transl Neurol. 2022 Sep;9(9):1392-1404. PMC9463947
• Rumora AE, Kim B, Feldman EL. A Role for Fatty Acids in Peripheral Neuropathy Associated with Type 2 Diabetes and Prediabetes. Antioxid Redox Signal. 2022 Sep;37(7-9):560-577. PMC9499450
• Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022 Oct;21(10):922-936.
• Bjornstad P, Dart A, Donaghue KC, Dost A, Feldman EL, Tan GS, Wadwa RP, Zabeen B, Marcovecchio ML. ISPAD Clinical Practice Consensus Guidelines 2022: Microvascular and macrovascular complications in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1432-1450.