portrait of Dr. Eva Feldman

Eva Feldman, MD, PhD

Russell N. DeJong Professor of Neurology
Director, NeuroNetwork for Emerging Therapies
Director, ALS Center of Excellence

Dr. Feldman is one of the world’s leading authorities on neurodegenerative disease. Currently, she serves as the Russell N. DeJong Professor of Neurology at the University of Michigan, as well as Director of the NeuroNetwork for Emerging Therapies and ALS Center of Excellence at Michigan Medicine.

Feldman has made contributions to biomedical research and clinical care in many critical areas of neurodegenerative disease.  Her primary focus has been on amyotrophic lateral sclerosis (ALS), Alzheimer's disease, cognitive decline, and the neurologic complications of diabetes and obesity, as well as how environmental toxins affect the nervous system. She also has conducted pioneering research on developing stem cell therapies to treat these diseases.

She is annually listed in Best Doctors in America and is a member of the Association of American Physicians and the National Academy of Medicine. She is a Fellow of the American Association for the Advancement of Science. Feldman has authored over 500 articles, 70 book chapters (Google Scholar h-index = 109) with >45,000 citations. She has been continuously NIH-funded since 1989 and has received numerous awards and honors throughout her remarkable career.

Credentials

  • BA, Biology and Chemistry, Earlham College, 73
  • MS, Zoology, University of Notre Dame, 75
  • PhD, Neuroscience, University of Michigan, 79
  • MD, Medicine, University of Michigan, 83
  • Residency, Neurology, Johns Hopkins Hospital, 87
  • Chief Resident, Neurology, Johns Hopkins Hospital, 86-87
  • Fellowship, EMG/Physical Medicine & Rehabilitation, University of Michigan Health System, 88

Select Honors & Awards

  • Annually listed in Castle Connolly's Best Doctors in America 
  • The American Clinical Neurophysiology Society Robert S. Schwab Award (2022)—the first woman to receive the award in its 25-year history
  • American Neurological Association’s Raymond D. Adams Lectureship Award (2021)
  • American Association for the Advancement of Science (AAAS) Fellow (2020)
  • Michigan Medicine Alumni Society Distinguished Achievement Award (2019) and Early Career Distinguished Achievement Award (2001)—the only alumnus to receive both awards
  • Peripheral Nerve Society Alan J. Gebhart Prize for Excellence in Peripheral Nerve Research (2019)
  • Marquis Who’s Who in the World Lifetime Award (2018)
  • Gerald D. Aurbach Award for Outstanding Translational Research, Endocrine Society (2017)
  • Castle Connolly National Physician of the Year Award for Clinical Excellence (2016)
  • Society for Neuroscience Bernice Grafstein Award for Outstanding Accomplishments in Mentoring (2016)
  • National Academy of Medicine of the National Academies of Sciences, Engineering and Medicine, Member (2014)
  • American Diabetes Association Lifetime Achievement Award (2006)
  • Juvenile Diabetes Research Foundation Mary Jane Kugel Award (2005, 2003)

Key Publications

  • Figueroa-Romero C, Guo K, Murdock BJ, Paez-Colasante X, … Taubman GF, McDermott AJ, O'Brien PD, Savelieff MG, Hur J, Feldman EL. Temporal evolution of the microbiome, immune system, and epigenome with disease progression in ALS mice.Dis Model Mech. 13(2):pii:dmm041947, 2019. PMC6906635
  • Goutman SA, Boss J, Guo K, Alakwaa FM, Patterson A, Kim S, Savelieff MG, Hur J, Feldman EL. Untargeted metabolomics yields insight into ALS disease mechanisms. J Neurol Neurosurg Psychiatry. 91(12):1329-1338, 2020. PMC7677469
  • Murdock BJ, Famie JP, Piecuch CE, Raue KD, Mendelson FE, Pieroni CH, Iniguez SD, Zhao L, Goutman SA, Feldman EL. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight. 6(11):e147129, 2021. PMC8262328.
  • Murdock BJ, Goutman SA, Boss J, Kim S, Feldman EL. Amyotrophic Lateral Sclerosis Survival Associates With Neutrophils in a Sex-specific Manner. Neurol Neuroimmunol Neuroinflamm. 2021 Feb 2;8(2):e953. PMC8057067
  • McGinley LM, Sims E, Lunn JS, Kashlan ON, Chen KS, Bruno ES, Pacut CM, Hazel T, Johe K, Sakowski SA, Feldman EL. Human cortical neural stem cells expressing insulin-like growth factor-I: A novel cellular therapy for Alzheimer’s disease. Stem Cells Transl Med. 2016 Mar;5(3):379-91. PMC4807660
  • McGinley LM, Kashlan ON, Chen KS, Bruno ES, Hayes JM, Backus C, Feldman S, Kashlan BN, Johe K, Feldman EL. Human neural stem cell transplantation into the corpus callosum of Alzheimer’s mice. Annals of Clinical and Translational Neurology, 4(10), 749-755, 2017. [non-NIH funded]
  • McGinley LM, Kashlan ON, Bruno ES, Chen KS, Hayes JM, Kashlan SR, Raykin J, Johe K, Murphy GG, Feldman EL. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep, 8(1), 14776, 2018. PMC6170460
  • Birger A, Ben-Dor I, Ottolenghi M, Turetsky T, Gil Y, Sweetat S, … Steiner D, Izrael M, Galun E, Feldman E, Behar O, Reubinoff B. Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity. EBioMedicine. 50:274-289, 2019. PMC6921360
  • Tadesse T, Gearing M, Senitzer D, Saxe D, Brat DJ, Bray R, Genel H, Hill C, Boulis N, Riley J, Feldman E, Johe K, Hazel T, Polak M, Bordeau J, Federici T, Glass JD. Analysis of graft survival in a trial of stem cell transplant in ALS. Ann Clin Transl Neurol. 1(11):900-8, 2014. PMC4265061
  • Glass JD, Hertzberg VS, Boulis NM, Riley J, Federici T, Polak M, Bordeau J, Fournier C, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges LF, Rutkove SB, Duell J, Patil PG, Goutman SA, Feldman EL. Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials. Neurology. 87(4):392-400, 2016. PMC4977116
  • Goutman SA, Brown MB, Glass JD, Boulis NM, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges L, Patil PG, Sakowski SA, Feldman EL. Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS. Ann Clin Transl Neurol. 5(6), 730-740, 2018. PMC5989736
  • Goutman SA, Savelieff MG, Sakowski SA, Feldman EL. Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials. Exp Opin Investig Drugs. 28(6):525-543, 2019. PMC6697143
  • Stino AM, Rumora AE, Kim B, Feldman EL. Evolving concepts on the role of dyslipidemia, bioenergetics, and inflammation in the pathogenesis and treatment of diabetic peripheral neuropathy. J Peripher Nerv Syst. 25(2):76-84, 2020. PMC7375363
  • Sajic M, Rumora AE, Kanhai AA, Dentoni G, Varatharajah S, Casey C, Brown RDR, Peters F, Hinder LM, Savelieff MG, Feldman EL, Smith KJ. High Dietary Fat Consumption Impairs Axonal Mitochondrial Function In Vivo. J Neurosci. 41(19):4321-4334, 2021. PMC8143198
  • Eid SA, Feldman EL. Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy. Dis Model Mech. 14(11):dmm049337, 2021. PMC8592018
  • Guo K, Savelieff MG, Rumora AE, Alakwaa FM, Callaghan BC, Hur J, Feldman EL. Plasma Metabolomics and Lipidomics Differentiate Obese Individuals by Peripheral Neuropathy Status. J Clin Endocrinol Metab. 2021 Nov 20:dgab844. PMCID – In Process.
  • Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic neuropathy: A position statement by the American Diabetes Association. Diabetes Care, 40(1), 136-154, 2017. PMC6977405
  • Rumora AE, Guo K, Alakwaa FM, Andersen ST, Reynolds EL, Jørgensen ME, Witte DR, Tankisi H, Charles M, Savelieff MG, Callaghan BC, Jensen TS, Feldman EL. Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes. Ann Clin Transl Neurol. 8(6):1292-1307, 2021. PMC8164865
  • Reynolds EL, Akinci G, Banerjee M, Looker HC, Patterson A, Nelson RG, Feldman EL, Callaghan BC. The determinants of complication trajectories in American Indians with type 2 diabetes. JCI Insight. 6(10):e146849, 2021. PMC8262294
  • Callaghan BC, Reynolds EL, Banerjee M, Akinci G, Chant E, Villegas-Umana E, Rothberg AE, Burant CF, Feldman EL. Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology. Obesity (Silver Spring). 29(12):2108-2118, 2021. PMC8612943