The overarching goal of Dr. Kretzler's research is to define chronic kidney disease in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal he and his team have developed a translational research pipeline centered on integrated systems biology analysis of renal disease.
Dr. Kretzler has 25 years of experience on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the United States, Europe, China, and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanisms identified have resulted in new disease predictors, new drug development and successful clinical trials of novel therapeutic modalities in chronic kidney disease.