The paper "Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy," recently published in Translational Research, was chosen by the Center for Cell Plasticity and Organ Design (CPOD) for their "Faculty Publication Spotlight."
From the COPD:
"Drs. Stephanie Eid and Eva Feldman et al. used RNAseq to understand the mechanisms underlying the distal-to-proximal progression of peripheral neuropathy in diet-induced obese animals. They found that the immune response, insulin signaling, and lipid metabolism were dysregulated both at distal and proximal sites, while oxidative stress was present only distally. These findings that are now published in Translational Research".
The mission of the Center for Cell Plasticity and Organ Design is to unite interdisciplinary research efforts toward understanding the basic mechanisms by which organs and tissues are formed and maintained and to use this knowledge to regenerate or create replacement tissues and organs, improve stem cell therapies and effective organ transplantation systems that will correct acquired and genetic human disease.