Biology - Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes

Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes

Objective

This study evaluated the efficacy of the drug empagliflozin, which reduces blood sugar levels and cardiovascular disease risk, on the progression of nerve, eye, and kidney diabetic complications in both type 1 and type 2 diabetes mouse models.
 

Conclusion

The research found that empagliflozin did not produce beneficial effects on disease progression in the type 2 diabetes model, but did improve nerve function in the type 1 diabetes model, which was accompanied by reduced markers of oxidative injury. These findings support our previous research that different mechanisms contribute to nerve damage in type 1 and type 2 diabetes. Our results also further support our view that a one-size-fit all therapy for all complications should be abandoned in favor of pursuing more personalized, tissue- and diabetes type-specific therapies.