Objective
This study aimed to identify clinical and biochemical risk factors, independent of blood glucose levels, for diabetic peripheral neuropathy and cardiovascular autonomic neuropathy in the large, well-characterized DCCT/EDIC cohort of participants with type 1 diabetes that have been followed for over 23 years.
Conclusion
Results demonstrated that after poor glucose control, age, diabetes duration, height, and certain other phenotypic features increased risk for peripheral neuropathy, while higher risk for cardiovascular autonomic neuropathy was associated with age, poor glucose control, sustained albuminuria, diabetes duration, etc. These findings highlight risk factors and phenotypes of participants with diabetic neuropathy that can be used in the design of new interventional trials and for personalized approaches to neuropathy prevention.