Journal of Diabetes and its Complications - Altered Plasma Serine and 1-deoxydihydroceramide Profiles are Associated with Diabetic Neuropathy in Type 2 Diabetes and Obesity

Altered Plasma Serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity


Recent studies suggest that the accumulation of “lipotoxic” atypical fats, such as 1-deoxydihydroceramides, may be associated with diabetic neuropathy (DN). This study investigated whether the level of these atypical lipotoxic fats correlated with DN severity and obesity in patients with type 2 diabetes (T2D).


1-deoxydihydroceramide levels increased step-wise from lean controls, to obese participants, to obese T2D participants, and were highest in obese T2D participants with DN. The researchers concluded that this atypical fat may be an important biomarker and/or mediator for DN.