Laryngoscope — Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration

Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration

Objective

Facial nerve injury can severely impact quality of life in affected individuals. Because nerve injury is often associated with inflammation, this study investigated how inducing an anti‐inflammatory environment during facial nerve reconstruction via a multichannel bridge containing interleukin‐4 (IL-4)-encoding lentivirus affected neuroregeneration following facial nerve gap injury in rodents.

Conclusion

This study demonstrated that placement of a multichannel bridge containing IL-4 improves regenerative outcomes in a rodent nerve injury model. This effect is likely mediated by promotion of an anti-inflammatory environment, and these findings may inform future therapeutic approaches to facial nerve injury.

Support