NIDDK - Integrated Systems Biology Approach to Diabetic Microvascular Complications

Integrated Systems Biology Approach to Diabetic Microvascular Complications

Dr. Eva Feldman was awarded this NIH grant (R24DK082841) to investigate microvascular complications in diabetes.

Microvascular complications refer to the gradual damage to nerve, eye, and kidney tissues during diabetes. Controlling blood glucose does not always prevent these from occurring, so Dr. Feldman and her team are investigating the effect of abnormal lipid (fats) profiles. They will look at tissue-specific effects of lipids in nerve, eye, and kidney and will will seek to identify lipid “signatures”, i.e., the presence or absence of specific lipids, that are linked to tissue-specific complications. It will also seek to identify potential lipids that could be possible treatment targets.