NIDDK - Sphingolipid and Fatty Acid Biology in Prediabetes and Neuropathy

Sphingolipid and Fatty Acid Biology in Prediabetes and Neuropathy

Dr. Rumora was awarded a grant from the National Institutes of Health (K99DK119366) to investigate a dietary method for preventing diabetes induced neuropathy. The goal is to identify monosaturated fat (MUFA) supplementation as an accessible and targeted therapy to reverse toxic ceramide accumulation and reverse or halt the progression of neuropathy. In this study, Dr. Rumora will determine whether a diet enriched in monounsaturated fatty acids, such as present in olive oil and other oils, instead of saturated fatty acids, such as found in butter, can prevent the development or severity diabetic neuropathy. She will also be investigating the link of a type of lipid called ceramides with diabetic neuropathy.