NIEHS - Mapping the ALS Exposome to Gain New Insights Into Disease Risk and Pathogenesis

Mapping the ALS Exposome to Gain New Insights Into Disease Risk and Pathogenesis

Dr. Eva Feldman and Dr. Stuart Batterman were jointly awarded a National Institutes of Health (NIH) grant (R01ES030049) on January 2020 to fund research into the effect of the environment on amyotrophic lateral sclerosis (ALS).  The goal is to collect data which will offer a foundation to uncover key pathways and mechanisms linked to exposure-induced changes that may identify biomarkers and therapeutic targets in ALS.

The environment contains toxic substances, such as persistent organic pollutants, pesticides, and heavy metals, that can injure nerves and cause neurological diseases. This grant begins to pinpoint which toxic environmental exposures increase the risk of developing ALS. The mechanism of toxic exposure-induced neurological injury can shed light onto pathological mechanisms in ALS, and identify possible therapeutic targets.