NINDS - Linking Nerve Bioenergetics with Metabolomics: New Insights into Diabetic Neuropathy

Linking Nerve Bioenergetics with Metabolomics: New Insights into Diabetic Neuropathy

Dr. Eva Feldman received this NIH grant (R21NS102924) to investigate the link between energy production and neuropathy in prediabetes and diabetes . The major goal of this project is to identify bioenergetics—how cells transform energy—pathways whose regulation play crucial roles in the pathogenesis of diabetic peripheral neuropathy.

Mitochondria are cellular structures that generate the energy needed for keep cells and organisms alive and may be defective during the development of neuropathy. This study will study how mitochondria fail in neuropathy and also if this is linked to the presence or absence of certain metabolites.

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