Understanding how oxidants contribute to nerve injury in diabetes
Dr. Stephanie Eid has served as a diabetes team leader for the NeuroNetwork for Emerging Therapies since January 2019. Her specific interest is understanding the molecular and cellular mechanisms by which oxidative stress injures nerves during diabetes, a condition known as diabetic neuropathy. She is studying free radical production in diabetes, and exploring its role in the onset and progression of nerve damage in diabetes. Dr. Eid uses cellular and animal models of diabetes as well as studies on patients with diabetes. Understanding how free radicals and oxidative stress contribute to nerve injury in diabetes will form the basis for mechanism-based design of new drug therapies.
Credentials
- BS/MS, Physiology, American University of Beirut, 2012
- PhD, Neuroscience, American University of Beirut/Paris Descartes University, Sorbonne Paris Cité, 2017
Honors & Awards
- The Angelika Bierhaus Prize in basic research, Neurodiab (diabetic neuropathy study group of the European Association for the Study of Diabetes)
- National Council for Scientific Research – Lebanon Fellowship
- Training Scholarship, Paris Descartes University
- Travel grant, Peripheral Nerve Society
- Travel grant, National Institute of Diabetes and Digestive and Kidney Diseases
Top Publications
Eid SA, Feldman EL. Advances in Diet-Induced Rodent Models of Metabolically Acquired Peripheral Neuropathy. Dis Model Mech. In press.
Eid S*, Hinder LM*, Zhang H*, Eksi R, Nair V, Eddy S, Eichinger F, Park M, Saha J, Berthier CC, Jagadish HV, Guan Y, Pennathur S, Hur J, Kretzler M, Feldman EL, Brosius FC. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: predictors of pathology and RAAS blockade effects. FASEB J. 35(5):e21467, 2021.
*The authors contributed equally to this work
Eid S*, Guo K*, Elzinga SE*, Pacut C, Feldman EL, and Hur J. Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes of Human Diabetic Neuropathy. Clin Epigenet. 2020, 12, 123.
*The authors contributed equally to this work
Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA*, Massaad C*. Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice. Diabetes. 2020, 69(3): 448-464.
Eid SA*, O'Brien PD*, Guo K*, Rumora AE*, Hinder LM*, Hayes JM, Mendelson FE, Hur J, Feldman EL. Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes. Dis Model Mech. 2020, 13(2).
*The authors contributed equally to this work
News
Dr. Stephanie Eid Receives Prestigious International Award
At the 31st Annual Meeting of NEURODIAB, Dr. Stephanie Eid was awarded the Angelika Bierhaus prize in basic research .
DMM: Drs. Feldman and Eid Invited to Write Special Perspective for World Diabetes Day
To celebrate World Diabetes Day and 100 years of insulin, Disease Models & Mechanisms published an examination of current diet-induced rodent models of peripheral neuropathy, a severe complication of type 2 diabetes.
DMM: 3 Publications Included in 100 Years of Insulin Celebration
It has been 100 years since the discovery of insulin. To celebrate this centenary, Disease Models & Mechanisms explores ongoing research in diabetes, including three publications from Drs. Eva Feldman, Stephanie Eid, Sarah Elzinga, and former lab member Dr. Phillip O'Brien.