Areas of Interest
The goal of our lab is to uncover the neuronal circuitry of sleep-wake states and sleep-preparatory behaviors, and to delineate the mechanisms involved in pathological alterations in these circuits. To accomplish these, we combine innovative techniques to record and manipulate neuronal circuits in rodents, including in-vivo calcium imaging using a head-mounted miniature microscope, fiber-photometry, optogenetics, chemogenetics, and circuit tracing with ethologically-relevant behavioral manipulations.
- VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors. Eban-Rothschild, A., Rothschild, G., Giardino, W.J., Jones, R.J. and de Lecea, L. Nature neuroscience 2016 19 1356-66.
- Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Giardino, W.J., Eban-Rothschild, A., Christoffel, D.J., Li, S.B., Malenka, R.C., de Lecea, L. Nature neuroscience 2018 21(8): p. 1084-1095.
- Neuronal mechanisms for sleep/wake regulation and modulatory drive. Eban-Rothschild, A. Appelbaum, L. and de Lecea, L. Neuropsychopharmacology 2018 43, 937-952
- To sleep or not to sleep: neuronal and ecological insights. Eban-Rothschild, A. Giardino, W.J. and de Lecea, L. Current Opinion in Neurobiology 2017 44,132-138