Areas of Interest
The Tidball lab studies the mechanisms of human developmental brain malformations, including neural tube defects and focal cortical dysplasia. We use single rosette brain organoids, pluripotent stem cells, and CRISPR technology to investigate novel genes that lead to these conditions. We also model the effects of neuroteratogens, compounds that disrupt development of the central nervous system when ingested during pregnancy.
Honors & Awards
- American Epilepsy Society Young Investigator Award (2022)
- American Epilepsy Society Fellow (2017)
Credentials
- B.S., Calvin College 2004 - 2008
- Ph.D., Vanderbilt University 2008 - 2014
- Postdoctoral Training, University of Michigan 2014 - 2019
Published Articles or Reviews
- Takla TN, Luo J, Sudyk R, Huang J, Walker JC, Vora NL, Sexton JZ, Parent JM, and Tidball AM. (2023). A shared pathogenic mechanism for valproic acid and SHROOM3 knockout in a brain organoid model of neural tube defects. Cells, 12(13), 1697.
- Tidball AM, Niu W, Ma Q, Takla TN, Walker JC, Margolis JL, Mojica-Perez SP, Sudyk R, Moore SJ, Chopra R, Shakkottai VG, Murphy GG, Li JZ, and Parent JM. (2022). Self-organizing single-rosette brain organoids from human pluripotent stem cells. Biorxiv, 2022-02.
- Tidball AM, Lopez-Santiago LF, Yuan Y, Glenn TW, Margolis JL, Walker JC, Kilbane EG, Miller CA, Bebin Em, Perry MS, Isom LL, and Parent JM (2020). Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons. Brain, 143(10), 3025-3040.
- Tidball AM, Dang LT, Glenn TW, Kilbane EG, Klarr DJ, Margolis JL, Uhler MD, and Parent JM. (2017). Rapid generation of human genetic loss-of-function iPSC lines by simultaneous reprogramming and gene editing. Stem cell reports, 9(3), 725-731.