Dr. Benjamin Singer is an Assistant Professor in Pulmonary and Critical Care Medicine in the Department of Internal Medicine at the University of Michigan. He received his undergraduate degree in mathematics at the University of Michigan in 2002. Dr. Singer completed his medical training and Ph.D. in Neuroscience through the Medical Scientist Training Program and subsequently completed his residency in Internal Medicine and fellowship training in Pulmonary and Critical Care Medicine, all at the University of Michigan.
Areas of Interest
Dr. Singer’s research focuses on basic and translational studies of long-term brain injury after critical illness, focusing on sepsis. These studies utilize animal models of sepsis and patient autopsy specimens to examine the immune and vascular responses to sepsis in the brain that persist for weeks to months after the outward signs of illness have resolved. How preexisting neuropathology, such as beta amyloid, might predispose sepsis survivors to brain dysfunction is al major area of interest. This work aims to identify strategies to minimize and rehabilitate ongoing brain injury in sepsis survivors. Areas of particular clinical focus include the care of patients with advanced neuromuscular disease requiring chronic assisted ventilation. Dr. Singer’s lab receives support from the National Institute on Aging and National Heart, Lung and Blood Institute and has received past support from the Michigan Alzheimer’s Disease Research Center, NINDS, the American Thoracic Society, MICHR, and the University of Michigan Depression Center.
Published Articles or Reviews
- Su SH, Song Y, Newstead MW, Cai T, Wu M, Stephens A, Singer BH, Kurabayashi K. Ultrasensitive Multiparameter Phenotyping of Rare Cells Using an Integrated Digital-Molecular-Counting Microfluidic Well Plate. Small. 2021 Aug;17(31):e2101743. doi: 10.1002/smll.202101743. Epub 2021 Jun 25. PubMed PMID: 34170616; PubMed Central PMCID: PMC8349899.
- Denstaedt SJ, Spencer-Segal JL, Newstead M, Laborc K, Zeng X, Standiford TJ, Singer BH. Persistent Neuroinflammation and Brain-Specific Immune Priming in a Novel Survival Model of Murine Pneumosepsis. Shock. 2020 Jul;54(1):78-86. doi: 10.1097/SHK.0000000000001435. PubMed PMID: 31415473; PubMed Central PMCID: PMC7015772.
- Bustamante AC, Opron K, Ehlenbach WJ, Larson EB, Crane PK, Keene CD, Standiford TJ, Singer BH. Transcriptomic Profiles of Sepsis in the Human Brain. Am J Respir Crit Care Med. 2020 Apr 1;201(7):861-863. doi: 10.1164/rccm.201909-1713LE. PubMed PMID: 31940219; PubMed Central PMCID: PMC7124721.
- Denstaedt SJ, Spencer-Segal JL, Newstead MW, Laborc K, Zhao AP, Hjelmaas A, Zeng X, Akil H, Standiford TJ, Singer BH. S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis. J Immunol. 2018 May 1;200(9):3188-3200. doi: 10.4049/jimmunol.1700834. Epub 2018 Mar 21. PubMed PMID: 29563178; PubMed Central PMCID: PMC5915914.