Benjamin Singer, M.D., Ph.D.

Dr. Singer’s research focuses on basic and translational studies of long-term brain injury after critical illness, focusing on sepsis. These studies utilize animal models of sepsis and patient autopsy specimens to examine the immune and vascular responses to sepsis in the brain that persist for weeks to months after the outward signs of illness have resolved. How preexisting neuropathology, such as beta amyloid, might predispose sepsis survivors to brain dysfunction is al major area of interest. This work aims to identify strategies to minimize and rehabilitate ongoing brain injury in sepsis survivors. Areas of particular clinical focus include the care of patients with advanced neuromuscular disease requiring chronic assisted ventilation. Dr. Singer’s lab receives support from the National Institute on Aging and National Heart, Lung and Blood Institute and has received past support from the Michigan Alzheimer’s Disease Research Center, NINDS, the American Thoracic Society, MICHR, and the University of Michigan Depression Center.