Areas of Interest
We study neural mechanisms of physiological (sleep, wakefulness) and pharmacological (anesthesia, psychedelic) states of consciousness in rodents. In our studies, we employ electroencephalographic recordings, in vivo neurotransmitter quantification, pharmacological interventions, and chemogenetic tools. We also use information-theoretic measures, complexity measures, and spectral analysis of electroencephalographic data to understand the neural changes accompanying different behavioral states.
Published Articles or Reviews
- Jon G Dean, Chris W Fields, Michael A Brito, Brian H Silverstein, Chloe Rybicki-Kler, Anna M Fryzel, Trent Groenhout, Tiecheng Liu, George A Mashour, Dinesh Pal. Inactivation of Prefrontal Cortex Attenuates Behavioral Arousal Induced by Stimulation of Basal Forebrain During Sevoflurane Anesthesia. Anesth Analg. 2022 Apr 18. PMID: 35436248
- Michael A Brito, Duan Li, Christopher W Fields, Chloe Rybicki-Kler, Jon G Dean, Tiecheng Liu, George A Mashour, Dinesh Pal. Cortical Acetylcholine Levels Correlate with Neurophysiologic Complexity During Subanesthetic Ketamine and Nitrous Oxide Exposure in Rats. Anesth Analg. 2021 Dec 20. PMID: 34928887
- Emma R Huels, Trent Groenhout, Christopher W Fields, Tiecheng Liu, George A Mashour, Dinesh Pal. Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia. Front Syst Neurosci., 2021 Jul 9;15:690717. doi: 10.3389/fnsys.2021.690717. eCollection 2021.
- Dinesh Pal, Duan Li, Jon G Dean, Michael A Brito, Tiecheng Liu, Anna M Fryzel, Anthony G Hudetz, George A Mashour. Level of Consciousness Is Dissociable from Electroencephalographic Measures of Cortical Connectivity, Slow Oscillations, and Complexity. J Neurosci., 2020 Jan 15;40(3):605-618. doi: 10.1523/JNEUROSCI.1910-19.2019. Epub 2019 Nov 27.