Areas of Interest
A major focus of the Murphy lab is studying how a class of proteins known as voltage gated ion channels regulate neuronal functions and complex behaviors such as learning and memory – specifically, how changes in neuronal excitability contribute to memory formation, storage and retrieval.
Voltage gated ion channels (in particular, calcium channels) selectively permit charged ions to cross the cell membrane, controlling a variety of neuronal functions. The Murphy lab is investigating the potential role of changes in the dynamics and expression of these channels in age-related cognitive decline, as well as in the development of Alzheimer’s disease and psychiatric diseases including bipolar disorder.
The Murphy lab also actively participates in team science taking place across the University, focused on topics including temporal lobe epilepsy, blood brain barrier dysfunction and axonal guidance.
- Cazares, V.A., Rodriguez, G., Parent, R., Ouillette, L., Glanowska, K.M., Moore, S.J., and Murphy, G.G., Environmental variables that ameliorate extinction learning deficits in the 129S1/SvlmJ mouse strain. Genes Brain Behav, 2019. 18(7): p. e12575. PMC6718342.
- Moore, S.J. and Murphy, G.G., The role of L-type calcium channels in neuronal excitability and aging. Neurobiology of Learning and Memory, 2020. 173: p. 107230.
- Ghoweri, A.O., Ouillette, L., Frazier, H.N., Anderson, K.L., Lin, R.-L., Gant, J.C., Parent, R., Moore, S., Murphy, G.G., and Thibault, O., Electrophysiological and Imaging Calcium Biomarkers of Aging in Male and Female 5XFAD Mice. Journal of Alzheimer's Disease, 2020. 78: p. 1419-1438.
- Rodriguez, G., Moore, S.J., Neff, R.C., Glass, E.D., Stevenson, T.K., Stinnett, G.S., Seasholtz, A.F., Murphy, G.G., and Cazares, V.A., Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice. Neurobiology of Stress, 2020. 13: p. 100262
For a complete list, please visit: http://www.ncbi.nlm.nih.gov/sites/myncbi/1dg2wcqznBMQd/bibliography/4044...