Areas of Interest
A major focus of the Murphy lab is studying how a class of proteins known as voltage gated ion channels regulate neuronal functions and complex behaviors such as learning and memory – specifically, how changes in neuronal excitability contribute to memory formation, storage and retrieval.
Voltage gated ion channels (in particular, calcium channels) selectively permit charged ions to cross the cell membrane, controlling a variety of neuronal functions. The Murphy lab is investigating the potential role of changes in the dynamics and expression of these channels in age-related cognitive decline, as well as in the development of Alzheimer’s disease and psychiatric diseases including bipolar disorder.
The Murphy lab also actively participates in team science taking place across the University, focused on topics including temporal lobe epilepsy, blood brain barrier dysfunction and axonal guidance.
Cazares VA, Murphy GG. Neural plasticity of the amygdala . In: Handbook of Amygdala Structure and Function. Urban J, Rosenkranz A, editors. Amsterdam, Netherlands: Elsevier; 2020. Chapter 5; p.in press.
Althaus AL, Moore SJ, Zhang H, Du X, Murphy GG, Parent JM. Altered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy. J Neurosci. 2019 Sep 18;39(38):7604-7614. doi: 10.1523/JNEUROSCI.0654-18.2019. Epub 2019 Jul 3. PubMed PMID: 31270158; PubMed Central PMCID: PMC6750946.
Cazares VA, Rodriguez G, Parent R, Ouillette L, Glanowska KM, Moore SJ, Murphy GG. Environmental variables that ameliorate extinction learning deficits in the 129S1/SvlmJ mouse strain. Genes Brain Behav. 2019 Sep;18(7):e12575. doi: 10.1111/gbb.12575. Epub 2019 May 7. PubMed PMID: 30973205; PubMed Central PMCID: PMC6718342.