Areas of Interest
The Ahmed lab studies behavioral neural circuits and attempts to repair them when they go awry in specific disorders. Working with patients and with transgenic rodent models, we focus on how space, time and speed are encoded by the spatial navigation and memory circuits of the brain, and how this information is consolidated during sleep. We also focus on how these same cells and circuits go wrong in Alzheimer's disease, Parkinson's disease, and epilepsy, with the goal of identifying novel targets for therapies.
Alzheimer's disease, Parkinson's disease, Epilepsy.
Published Articles or Reviews
Ahmed OJ (2021). Mechanisms of subiculum hyperexcitability in temporal lobe epilepsy. Epilepsy Currents In Press [LINK]
Brennan EW*, Jedrasiak-Cape I*, Kailasa S*, Rice SP, Sudhakar SK, Ahmed OJ (2021). Thalamus and claustrum control parallel layer 1 circuits in retrosplenial cortex. eLife 10:e62207[PDF] [LINK] [eLife DIGEST] [PRESS]
Zardini AS, Rostami B, Najafi K, Hetrick VL, Ahmed OJ (2021). Sea of Electrodes Array (SEA): Extremely Dense and High-Count Silicon-Based Electrode Array Technology for High-Resolution High-Bandwidth Interfacing with 3D Neural Structures. [bioRxiv PREPRINT]
Ahmed OJ, John TT, Sudhakar SK, Brennan EKW, Lorenzo Gonzalez A, Naftulin JS, Eskandar E, Madsen JR, Cosgrove GR, Blum AS, Potter NS, Mashour GA, Hochberg LR, Cash SS (2021). Two modes of inhibitory neuronal shutdown distinctly amplify seizures in humans. submitted [medRxiv PREPRINT]