Sharan Srinivasan, M.D., Ph.D.

Michigan Neuroscience Institute Affiliate
Assistant Professor, Neurology

1914 Taubman
1500 E. Med Ctr Dr
Ann Arbor MI 48109-0322



Dr. Sharan Srinivasan is an Assistant Professor within the Movement Disorders Division in the Department of Neurology at the University of Michigan. He attended Northwestern University for his bachelor's degree and obtained his combined M.D. Ph.D. at the University of Michigan. He then completed his residency in Neurology at the University of Michigan before pursuing a movement disorders fellowship at Mass General Brigham (Harvard). He returned to the University of Michigan in 2022 to continue his clinical and scientific efforts in caring for and treating cerebellar ataxias.

Areas of Interest

His clinical and research interests involve the pathophysiology of cerebellar ataxias, particularly hereditary polyglutamine disorders. His passion is in developing novel therapeutics via a multidisciplinary approach, combining strategies from organic chemistry, molecular biology, neuro-circuitry, and emerging genetic technologies. His focus has been on targeting impaired neuronal circuitry within these disorders, amelioration of which has been shown to improve motor symptoms and delay degeneration.

Clinical Interests

Hereditary polyglutamine ataxias, sporadic cerebellar ataxias


  • B.A., Integrated Science, Biochemistry, Molecular Biology and Genetics (Northwestern University)
  • M.D., Ph.D., (University of Michigan Medical School)
  • Residency, Neurology (Michigan Medicine)
  • Fellowship, Mass General Brigham – Movement Disorders (Harvard)
  • Board Certification, ABPN (Neurology and Psychiatry)

Published Articles or Reviews

  • Srinivasan, S.R. “Targeting Circuit Abnormalities in Neurodegenerative Disorders”. (2023). Mol. Pharmacology 103(1):38-44.
  • Srinivasan, S.R., Huang, H., Chang, W-C., Strassmaier, T., and Shakkottai, V.G. “Discovery of novel activators of large-conductance calcium-activated potassium channels for the treatment of cerebellar ataxia.” (2022)Mol. Pharmacology 102(1):438-449.
  • Powers, R., Paulson, H., and Srinivasan, S.R.* “Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies.” (2023) Contemporary Clinical Neuroscience. *Corresponding author.
  • Srinivasan, S.R.; Melo de Gusmao, Claudio; Korecka, J.A.; Khurana, V. “Repeat Expansion Disorders”, Neurobiology of Disease (2022).
  • Srinivasan, S.R. and Shakkottai, V.G. “Moving Towards Therapy in SCA1: Insights from Molecular Mechanisms, Identification of Novel Targets, and Planning for Human Trials.” (2019) Neurotherapeutics. (DOI 10.1007/s13311-019-00763-y).