Dr. Yin is Assistant Professor of Molecular & Integrative Physiology. Dr. Yin’s lab investigates the functional link between insulin signaling and molecular clock in liver and its potential role in insulin resistance. Our initial results suggest that insulin signaling is tightly associated with circadian clock in liver cells, suggesting a functional crosstalk between these two pathways. We want to explore this finding using both cell culture and animal model. We have generated adenovirus for expressing or knocking down the core clock proteins and those reagents will be used to manipulate liver specific clock using tail-vein injection approach and then study insulin signaling and insulin function. The experimental approaches include RNA extractin, QPCR, protein isolation, immunoblotting as well as immunoprecipitation.
Research Associate Professor, Molecular & Integrative Physiology
My research interest is in studying posttranslational modifications of transcription factors in glucose and lipid metabolism. A combination of genetic, molecular and biochemical approaches is employed to elucidate the molecular mechanisms underlying the posttranslational modifications as well as the physiological consequences on glucose and lipid homeostasis.
Student Program Administrator
Heather is the coordinator of the STEP Program, as well as the SURF & SURP Programs. You can contact her at firstname.lastname@example.org.