Huilun Wang

Eugene Chen Lab


Krüppel-like factor 14 (KLF14), a zinc finger transcription factor, has been identified by GWAS that is correlated with HDL-C and blood glucose level in the population. As suggested by following biological studies, KLF14 expression level was found to be negatively associated with the development of T2DM, atherosclerosis, dyslipidemia, immune dysfunction and tumorgenesis, which promise KLF14 to be a potential target for treating multiple metabolic dysfunctions. My project so far is focusing on the role of KLF14 in glucose metabolism, and will go further into other physiological processes as well as diseases. My research will derive a detailed understanding of KLF14 function in metabolism, and provide a potential strategy for the treatment and prevention of multiple metabolic diseases.