Areas of Interest
I create mathematical models (including, but not limited to, ordinary differential equation models) of the biochemical reaction networks underlying metabolic pathways in cells. Systems I have investigated include both the normal (energy production in cardiac cells) and the pathological (acetaminophen overdose and chronic exposure to arsenic in liver cells). The distinguishing feature of my approach to modeling biochemical reaction networks, acquired under the mentorship of Daniel A. Beard, is guaranteed compliance of model behavior with the laws of physics, achieved by using stoichiometric (conservation of mass) and thermodynamic (i.e., Second Law) constraints.