Shijiao Huang, PhD

Research Investigator, Molecular & Integrative Physiology

3378 BSRB
Ann Arbor MI 48109-2200


Areas of Interest

My scientific goal is to understand the mechanisms of aging and to develop clinically relevant drugs to delay aging and enhance human health and longevity.

Honors & Awards

  • 02/2020 Nomination of Outstanding UROP Mentor Award for the 2019-2020 academic year
  • 09/2019 Postdoc180 Finalist, University of Michigan Medical School
  • 06/2019 Travel Award, University of Michigan Medical School
  • 04/2019 Best Poster Award, The 7th Midwest C. elegans meeting



  • Ph D, Cell Biology, Peking University

Published Articles or Reviews

  • Huang S, Howington M, Dobry C, Evans CR, Leiser SF. Flavin-Containing Monooxygenases are conserved regulators of stress resistance and metabolism. Frontiers in Cell and Developmental Biology. 2021. doi: 10.3389/fcell.2021.630188.
  • Beydoun S, Choi HS, Dela-Cruz G, Kruempel J, Huang S, Bazopoulou D, Miller HA, Schaller ML, Evans CR, Leiser SF. An alternative food source for metabolism and longevity studies in Caenorhabditis elegans. Communications Biology. 2021. (Accepted)
  • Kruempel JCP, Miller HA, Schaller ML, Fretz A, Howington M, Sarker M, Huang S, Leiser SF. Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response. Geroscience. 2020 Dec;42(6):1621-1633. PMID: 32399915; PMCID: PMC7732922.
  • Huang S, Wang Y. Golgi structure formation, function, and post-translational modifications in mammalian cells [version 1; peer review: 5 approved] F1000Research. 2017, 6(F1000 Faculty Rev):2050. PMID: 29225785; PMCID: PMC5710388.
  • Xu X*, Huang S*, Zhang B, Huang F, Chi W, Fu J, Wang G, Li S, Jiang Q, Zhang C. DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6. Nature Communications. 2017 Apr 27; 8:15164. PMID: 28447620; PMCID: PMC5414174. (*: Equal Contribution)
  • Huang S, Tang D, Wang Y. Monoubiquitination of syntaxin 5 regulates Golgi membrane dynamics during the cell cycle. Developmental Cell. 2016 Jul 11;38(1):73-85. PMID: 27404360; PMCID: PMC4942811.
  • Huang S*, Xu X*, Wang G, Lu G, Xie W, Tao W, Zhang H, Jiang Q, Zhang C. DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. Journal of Cell Science. 2016 Apr 1;129(7):1429-40. PMID: 26872786. (*: Equal Contribution)
  • Tang D, Zhang X, Huang S, Yuan H, Li J, Wang Y. Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking. Molecular Biology of the Cell. 2016 Jan 1;27(1):137-52. PMID: 26538023; PMCID: PMC4694753.
  • Liu X, Wei W, Huang S, Lin S, Zhang X, Zhang C, Du Y, Ma G, Li M, Mann S, Ma D. Bio-inspired protein-gold nanoconstruct with core-void-shell structure: beyond a chemo drug carrier. Journal of Materials Chemistry. B 06/2013; 1(25):3136-3143. doi: 10.1039/C3TB20081G.
  • Huang S, Zhang C. The Coordination between DNA Replication initiation and Other Cell Cycle Events. DNA Replication-Current Advances. InTech. 2011 August; doi: 10.5772/21646.
  • Huang S, Lu F, and Zhang C, 2011. Eukaryotic DNA replication initiation regulation. Molecular Cell Biology (Ed: Yeguang Chen, Chuanmao Zhang, Quan Chen). Tsinghua University Press, China. 389-402.
  • Chen Q, Huang S, and Zhang C, 2011. Spindle assembly during cell division. Molecular Cell Biology (Ed: Yeguang Chen, Chuanmao Zhang, Quan Chen). Tsinghua University Press, China. 376-388.

Web Sites