Since 1986 I have been working to resolve the connection between our evolutionary human history and our phenotype including disease. I have taken a purely physical approach using fundamental laws (e.g., 2nd Law of Thermodynamics). Progress is slow, and sometimes intercepted, because many biologists operate with the tenant that biology operates within its own set of fundamental principles, such as natural selection, that are not resolvable within the bounds of physics. Our rat biology work over the last 30 years strongly supports operation of the Energy Transfer Hypothesis (ETH).

Rob Williams, founder of the Complex Trait Consortium in 2002 has taken collaborative interest in our rats.
He writes “Lovely review https://doi.org/10.1093/function/zqac030 of this massive project. Bravo on cutting this important trail in research.”
Rob proposes to predict max VO2 (ETH) just from the genotypes of random bred Heterogenous Stock rats. This will get right at cause and effect at the genome-phenome level. Koch and I will provide theory predicting the path for this origination from the Big Bang.

The physical basis of health and disease phenotypes.