Elinor Levine Professor of Dementia Research
Professor of Neurology
[email protected]
Available to mentor
Catherine C Kaczorowski, BA, PhD
Professor
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FellowshipMedical College of Wisconsin, Neuroproteomics of Alzheimer's, Kern Innovation Fellow, 2012
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FellowshipUniversity of Wisconsin–Milwaukee, Psychology, Cognitive Aging, 2009
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PhDNorthwestern University - Institue for Neuroscience, Evanston, IL, 2006
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BAUniversity of Wisconsin–Milwaukee, Milwaukee, WI, 2000
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N/AFront Range Community College, Westminster, CO, 1997
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberPrecision Health Initiative
My laboratory pioneers techniques to identify and validate genetic and cellular mechanisms that promote resilience to cognitive aging, Alzheimer's disease, and other age-related dementias. By combining mouse and human systems; genomic, anatomic, and behavioral approaches; and integrative analyses across multiple scales, data types, environmental factors, and species, we are accelerating discovery of the precise genetic mechanisms of cognitive resilience that could yield the next generation of targets and therapeutic strategies for promoting brain health. We are now uniquely poised to propel the field of personalized medicine forward using our genetically diverse, yet reproducible models of human neurodegenerative dementias, having already contributed conceptual and technical advances that revolutionized our ability to study complex diseases, specifically human AD dementia.
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Wan Y-W, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao P-C, Tsai L-H, Haure-Mirande J-V, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein H-U, Accelerating Medicines Partnership-Alzheimer’s Disease Consortium , Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Ertekin-Taner N, Liu Z, Shulman JM, Mangravite LM, Logsdon BA. Cell Rep, 2020 Jul 14; 32 (2): 107908Journal ArticleMeta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
DOI:10.1016/j.celrep.2020.107908 PMID: 32668255 -
Wan Y-W, Al-Ouran R, Mangleburg CG, Lee TV, Allison K, Neuner S, Kaczorowski C, Phillip V, Howell G, Martini-Stoica H, Zheng H, Kim JW, Dawson V, Dawson T, Pao P-C, Tsai L-H, Haure-Mirande J-V, Wang M, Ehrlich ME, Mei H, Zhong X, Chakrabarty P, Levites Y, Golde TE, Levey AI, Consortium AMP-AD, Logsdon B, Mangravite L, Liu Z, Shulman JM. bioRxiv,PreprintFunctional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models
DOI:10.1101/506873 -
Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLoS Genet, 2021 Apr; 17 (4): e1009406Proceeding / Abstract / PosterPLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.
DOI:10.1371/journal.pgen.1009406 PMID: 33830999 -
Saul MC, Litkowski EM, Hadad N, Dunn AR, Boas SM, Wilcox JAL, Robbins JE, Wu Y, Philip VM, Merrihew GE, Park J, De Jager PL, Bridges DE, Menon V, Bennett DA, Hohman TJ, MacCoss MJ, Kaczorowski CC. 2024 Jan 11;PreprintHippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population.
DOI:10.1101/2024.01.09.574219 PMID: 38260300 -
Berchulski MR, Singh S, Martin SLA, O'Connell KM, Kaczorowski CC. Alzheimer's & Dementia, 2023 Dec; 19 (S13):Journal ArticleApoE variant associated with cognitive resilience alters AD associated hyperexcitability in dentate granule neurons
DOI:10.1002/alz.076851 -
Boas SM, Saul MC, Anderson D, Philip VM, Ramirez P, Frost B, Beck CR, Kaczorowski CC. Alzheimer's & Dementia, 2023 Dec; 19 (S24):Journal ArticleChromosome Y‐haplotype mediates cognitive resilience and differential expression of transposable elements in 5xFAD‐carrying AD‐BXD males
DOI:10.1002/alz.082951 -
MacDonald B, Kaur H, Tooley A, Zuberi A, Lutz C, O'Connell KM, Dunn AR, Kaczorowski CC. Alzheimer's & Dementia, 2023 Dec; 19 (S24):Journal ArticleGeneration and screening of mouse models of ADRD with multiple genetic manipulations to model dementia with mixed brain pathologies
DOI:10.1002/alz.083158 -
Litkowski EM, Dai M, Dunn AR, Bridges D, O'Connell KM, Kaczorowski CC. Alzheimer's & Dementia, 2023 Dec; 19 (S24):Journal ArticleGenetics and diet explain sex differences in glucose metabolism and cognitive function
DOI:10.1002/alz.082683
Department News
A man was identified with a rare mutation that protects from Alzheimer’s Disease.
