109 Zina Pitcher Place, 5017 AAT-BSRB
Ann Arbor, MI 48109
Available to mentor
I am the Russell N. DeJong Professor of Neurology, Director of the NeuroNetwork for Emerging Therapies, and Director of the University of Michigan Neuropathy Center and ALS Center of Excellence. I am annually listed in Best Doctors in America, a Past President of the Peripheral Nerve Society and American Neurological Association (ANA), a member of the National Academy of Medicine and Association of American Physicians, and a Fellow of the American Association for the Advancement of Science. As of summer 2020, I am Chair of the Neurology and Psychiatry Section of the National Academy of Medicine. My work is internationally recognized and published in >500articles and 70 book chapters (Google Scholar h-index = 109), with over 45,000 citations. I have been continuously NIH funded since 1989, and I oversee an established laboratory of 25 exceptional scientists. My laboratory develops novel cellular, gene, and growth factor therapies for neurologic disorders. I conducted pioneering studies on the pathogenesis of neuropathy in metabolic diseases, leveraging in vitro and in vivo models, clinical specimens, and multiple omics-based approaches, and identified dyslipidemia during diabetes as a key driver of nervous system damage, leading to new clinical patient care guidelines by the American Diabetes Association. I also developed a clinical tool to diagnose diabetic neuropathy that is used worldwide and in multiple NIH clinical trials. I have a strong track record of successful collaborations, and am a pioneer in directly transforming basic research into advances in clinical treatment. I led the first and only FDA-approved Phase 1 and 2 trials of direct spinal cord stem cell transplantation in amyotrophic lateral sclerosis (ALS). We are planning a Phase 3 trial and developing a similar cellular therapy for Alzheimer’s disease. I established an ALS biorepository to facilitate studies to increase our understanding of disease pathogenesis, and uncovered epigenetic, metabolomic, and immunological mechanisms representing potential biomarkers and therapeutic targets, and further identified environmental toxins as risk factors. I have mentored over 100 postdoctoral and clinical fellows and 9 neuroscience graduate students, and I was PI of the University of Michigan T32 NIH/NINDS Training in Clinical and Basic Neuroscience for ~2 decades. Thus, I have a long-standing history of effective biomedical research, translational clinical applications, leadership, and career development and mentoring.
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FellowUniversity of Michigan, Neuromuscular Disorders, 1998
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ResidencyJohns Hopkins Hospital, Neurology, 1987
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Chief ResidentJohns Hopkins, Neurology, 1987
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InternshipWilliam Beaumont Hospital, Internal Medicine, 1984
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MD, MedicineUniversity of Michigan Medical School, Ann Arbor, 1983
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PhD, NeuroscienceUniversity of Michigan Medical School, Ann Arbor, 1979
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MS, ZoologyUniversity of Notre Dame, South Bend, 1975
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BA, Biology and ChemistryEarlham College, Richmond, 1973
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberBiosciences Initiative
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberTaubman Institute
Diabetes and obesity complications
Peripheral neuropathy
Cognitive decline
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
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Griffin JW, Cornblath DR, Alexander E, Campbell J, Low PA, Bird S, Feldman EL. Ann Neurol, 1990 Mar; 27 (3): 304 - 315.Journal ArticleAtaxic sensory neuropathy and dorsal root ganglionitis associated with Sjögren's syndrome.
DOI:10.1002/ana.410270313 PMID: 2327738 -
Pestronk A, Chaudhry V, Feldman EL, Griffin JW, Cornblath DR, Denys EH, Glasberg M, Kuncl RW, Olney RK, Yee WC. Ann Neurol, 1990 Mar; 27 (3): 316 - 326.Journal ArticleLower motor neuron syndromes defined by patterns of weakness, nerve conduction abnormalities, and high titers of antiglycolipid antibodies.
DOI:10.1002/ana.410270314 PMID: 2327739 -
Feldman W, Feldman E, Goodman JT. Pediatrics, 1988 Feb; 81 (2): 190 - 194.Journal ArticleCulture versus biology: children's attitudes toward thinness and fatness.
PMID: 3422404 -
Feldman W, Woodward CA, Hodgson C, Harsanyi Z, Milner R, Feldman E. Can Med Assoc J, 1983 Dec 15; 129 (12): 1279 - 1283.Journal ArticleProspective study of school injuries: incidence, types, related factors and initial management.
PMID: 6652594 -
Feldman EL, Axelrod D, Schwartz M, Heacock AM, Agranoff BW. J Neurobiol, 1981 Nov; 12 (6): 591 - 598.Journal ArticleStudies on the localization of newly added membrane in growing neurites.
DOI:10.1002/neu.480120607 PMID: 7310397 -
Schwartz M, Axelrod D, Feldman EL, Agranoff BW. Brain Res, 1980 Jul 21; 194 (1): 171 - 180.Journal ArticleHistological localization of binding sites of alpha-bungarotoxin and of antibodies specific to acetylcholine receptor in goldfish optic nerve and tectum.
DOI:10.1016/0006-8993(80)91326-8 PMID: 7378835 -
Agranoff BW, Feldman EL, Heacock AM, Schwartz M. Neurochem Int, 1980 1C: 487 - 500.Journal ArticleThe retina as a biochemical model of central nervous system regeneration.
DOI:10.1016/0197-0186(80)90082-0 PMID: 20487757 -
Henn RE, Elzinga SE, Glass E, Parent R, Guo K, Allouch AM, Mendelson FE, Hayes J, Webber-Davis I, Murphy GG, Hur J, Feldman EL. Immun Ageing, 2024 Feb 21; 21 (1): 16Journal ArticleCorrection: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice.
DOI:10.1186/s12979-024-00422-7 PMID: 38383401