January 18, 2019

Neurology/Neuroscience Research Seminar - Presented by Bing Ye, PhD - Friday, January 18th

12:00 PM to 1:00 PM

Biomedical Science Research Building (BSRB), Room 5515, 109 Zina Pitcher Place, Ann Arbor, MI 48109

The roles of Down syndrome genes in neuronal development and brain disorders

Abstract:
The molecular mechanisms that underlie neurodevelopmental disorders in Down syndrome (DS) are poorly understood. DS is caused by the trisomy of human chromosome 21 (hCh21); different aspects of DS are caused by different genes on this chromosome. In consequence, a major hurdle in developing treatments for DS is the identification of genes and molecular pathways that are the drivers of pathogenesis and can be targeted for effective therapies. We discovered that the expression level of the Down syndrome cell adhesion molecule (DSCAM) instructs the growth of presynaptic terminals in Drosophila. DSCAM levels are increased in the brains of DS patients. We thus investigated the possible role of DSCAM in the pathogenesis of DS brain disorders. We found that the presynaptic terminals of Chandelier cells (ChCs), which are a major type of inhibitory neurons in the neocortex, are overgrown in DS mouse models. Histological and physiological studies show that DSCAM plays a major role in the presynaptic overgrowth in DS mice. These findings suggest that DSCAM contributes to neurodevelopmental defects in DS, and elucidate a productive approach for identifying genes that drive the pathogenesis of DS by using Drosophila.

Bing Ye

Associate Professor
Burton L. Baker Collegiate Professor of the Life Sciences
Research Focus: Neuron, development, circuit, dendrite, axon, brain disorders, Drosophila, mouse
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