Friday, April 19, 2019

Neurology/Neuroscience Research Seminar - Presented by Dr. Stefanie Geisler, Assistant Professor in the Department of Neurology, at Washington University in Saint Louis - Friday, April 19th

12:00 PM to 1:00 PM

Biomedical Science Research Building (BSRB), Room 5515, 109 Zina Pitcher Place, Ann Arbor, MI 48109

Axon degeneration in chemotherapy-induced neuropathy – from mechanisms to therapies


Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent dose-limiting toxicity caused by anti-cancer therapy. Unfortunately, there are no therapies to prevent CIPN. Most chemotherapy-induced neuropathies are characterized by early axonal degeneration. In recent years, others and we have made major breakthroughs in defining the mechanism of axon degeneration in CIPN. We discovered that chemotherapeutic agents with different mechanisms of action activate the neuronal protein SARM1, which then cleaves NAD+ thereby inducing axon degeneration to cause neuropathy. We have developed therapeutic strategies that potently block axon degeneration in cellular models of neuropathy and after nerve transection in living mice.

Accreditation and Credit Designation:

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Michigan Medical School designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Dr. Stefanie Geisler

Dr. Stefanie Geisler

Dr. Stefanie Geisler is a board certified Neurologist with subspecialty certification in Neuromuscular Medicine. She received her MD from the Charite, the Medical School of the Humboldt University in Berlin, Germany. Her thesis work focused on the subnuclear organization of the habenular complex. Her subsequent post-doctoral research with Scott Zahm at the Saint Louis University School of Medicine and Roy Wise at NIH/National Institute on Drug Addiction concerned the anatomical, neurochemical and behavioral organization of the mesolimbic dopamine system. She then completed the residency program in neurology, followed by the neuromuscle fellowship, both at Washington University in Saint Louis. During residency, she joined the laboratory of Aaron DiAntonio (Developmental Biology). There and in collaboration with Jeffrey Milbrandt (Genetics) she developed her current interest in molecular mechanisms in peripheral neuropathies, which she presently continues to investigate in her laboratory in the Department of Neurology at Washington University.