September 13, 2019

Neurology/Neuroscience Research Seminar - Presented by Dr. Daryl Bosco, Associate Professor, Neurology, University of Massachusetts Medical School - Friday, September 13th, 2019

12:00 PM to 1:00 PM

Biomedical Science Research Building (BSRB), Room 5515, 109 Zina Pitcher Place, Ann Arbor, MI 48109

Stressed to death: altered stress response and recovery in neurodegenerative disease

Various forms of cellular stress such as oxidative stress and excitotoxicity have been implicated in neurodegeneration. Our laboratory is investigating the role of stress in neurological disorders, primarily in the context of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS and FTD are two fatal neurodegenerative disorders with overlapping clinical and pathological features. We have found that expression of ALS/FTD-associated proteins such as Fused in Sarcoma (FUS) induces a ‘stressed state’ in neurons, affecting processes in both the axon and cell body. For example, mutant FUS triggers the activation of stress-related enzymes that inhibit axonal transport and degrade nuclear pores. Neurons respond to acute forms stress through the formation of membrane-less RNA granules called stress granules, which are thought to play a protective role in stress response. However, the association of disease-linked proteins, including FUS, with stress granules may compromise cellular stress response pathways and promote pathological protein aggregation. As will be discussed in this seminar, we are exploring the vulnerability of neurons to disease-linked proteins that both cause stress and prevent neurons from effectively overcoming stress.

Accreditation and Credit Designation:

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Michigan Medical School designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

 
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Dr. Daryl Bosco

Daryl Bosco, PhD

Associate Professor, Neurology, University of Massachusetts Medical School