October 18, 2019

Neurology/Neuroscience Research Seminar - Presented by Dr. Eleni Gourgou, Assistant Research Scientist, Mechanical Engineering - Friday, October 18th, 2019

12:00 PM to 1:00 PM

Biomedical Science Research Building (BSRB), Room 5515, 109 Zina Pitcher Place, Ann Arbor, MI 48109

C. elegans learning and decision making in a structured environment

 

C. elegans' ability to exhibit associative, non-associative and imprinted memory in the context of chemical stimuli is well studied. Here, we demonstrate that C. elegans are capable of associative learning of spatial cues in a maze-structured environment.  By using a custom-made Worm-Maze platform, we show that C. elegans young adults can locate food in T-shaped mazes and, following that experience, learn to reach a specific maze arm. Our results show that C. elegans learning of spatial information is possible after a single training session and that it affects their decision-making, even in the presence of conflicting environmental cues. We also provide evidence that C. elegans learning of spatial cues is a multi-sensory behavior, which requires chemosensory and mechanosensory inputs and involves a CREB-like transcription factor and dopamine signaling.

Accreditation and Credit Designation:

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Michigan Medical School designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Scan the QR code to register your attendance.

*For iOS devices: Open the phone's camera app and hover over the code. When the notification box appears, tap on it to open the credit claiming screen.
For Android Devices: A QR reader is required. Visit the Google Play store to download a QR app of your choice. Follow the scanning directions provided by the app.

* Please Note: Attendance must be registered within 6 months to be awarded credit. To complete an evaluation for this session, please login to MiCME and go to the Claim Credits & Print Transcripts page.

C. elegans learning and decision making in a structured environment

Dr. Eleni Gourgou

Eleni Gourgou, PhD

Assistant Research Scientist, Mechanical Engineering