Friday, January 17, 2020

Neurology/Neuroscience Research Seminar - Presented by Nandakumar Narayanan, MD, PhD - University of Iowa - Friday, January 17th, 2020

12:00 PM to 1:00 PM

Biomedical Science Research Building (BSRB), Room 5515, 109 Zina Pitcher Place, Ann Arbor, MI 48109

“Of cortex and cognition in Parkinson's disease”

Cognitive dysfunction is a source of major disability in Parkinson's disease. The cause of PD-related cognitive dysfunction is unknown. We have found that PD patients have increased variability during interval timing, or estimating intervals of several seconds. This variability is correlated with attenuated ~ 4 Hz cortical rhythms. Strikingly, our work suggests that rodents have similar 4 Hz cortical rhythms during interval timing, and these rhythms require cortical dopamine in rodent PD models. We have found that these 4 Hz brain rhythms synchronize cortical networks in service of cognitive control. We discuss strategies to exploit 4 Hz synchrony to compensate for dopamine-dependent deficits in cognitive function.

Accreditation and Credit Designation:

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Michigan Medical School designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Dr. Nandakumar Narayanan

Nandakumar Narayanan, MD, PhD

Associate Professor and Vice Chair for Basic and Translational Research, Neurology, University of Iowa