Friday, March 6, 2020

Neurology/Neuroscience Research Seminar - Presented by Evan Reynolds, PhD, Research Fellow (T32) Department of Neurology - Friday, March 6th, 2020

12:00 PM to 1:00 PM

Biomedical Science Research Building (BSRB), Room 5515, 109 Zina Pitcher Place, Ann Arbor, MI 48109

The association between the metabolic syndrome and traditional diabetic complications in the severely obese

We aimed to identify risk factors from the metabolic syndrome that are associated with traditional diabetic complications and cognitive function. We performed a cross-sectional, observational study in obese individuals awaiting bariatric surgery. Distal symmetric polyneuropathy was defined by the Toronto consensus definition of probable neuropathy. Cognitive deficits were defined by the NIH cognitive toolbox (<5th percentile for lean controls). Cardiovascular autonomic neuropathy was defined by expiration/inspiration (E/I) ratio (<5th percentile for lean controls). Retinopathy was based on retinal photographs and nephropathy on eGFR (<60 mg/dL) and/or albumin to creatinine ratio (>/= 30mg/g). To better understand how the distribution of weight impacts these outcomes, we performed a ROC analysis to determine which of 9 anthropometric measurements were most associated with each complication. We found that obesity alone is likely sufficient to cause neuropathy and cognitive deficits, but not retinopathy or nephropathy. Additionally, central obesity is
the key metabolic risk factor for neuropathy and cognitive function.

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The association between the metabolic syndrome and traditional diabetic complications in the severely obese