Friday, March 19, 2021

Neurology/Neuroscience Research Seminar

12:00 PM to 1:00 PM

CME credit available, click here

Virtual event

Zoom ID: 910 4550 7427 Passcode: 776945

“Molecularly Distinct Roles of Chromatin Regulation in Cortical Development"

Nuclear DNA is packaged into chromatin, which compacts the genome, but also constrains biological processes on DNA. Reorganizing chromatin is therefore a key step in all transactions on genomic DNA, including transcriptional regulation, DNA replication, and DNA damage repair. Chromatin reorganization is mediated by chromatin remodelers: ATP-dependent complexes that reposition nucleosomes on DNA, evict nucleosomes from DNA, or exchange histone subunits, thereby controlling accessibility, flexibility, and mobility of chromatin. Emerging human genetic findings convergently implicate dysregulation of chromatin as a key contributor to developmental brain disorders. The diverse roles of chromatin regulation in neurodevelopment are an active field of study. In this seminar, I will present our recent work on two chromatin remodelers associated with a disorder of brain development, Arid1a (Coffin-Siris syndrome) and Ino80 (microcephaly with intellectual disability). The distinct roles of these remodelers in transcriptome versus genome maintenance will be discussed.