Friday, March 26, 2021

Neurology/Neuroscience Research Seminar

12:00 PM to 1:00 PM

CME credit available, click here

Virtual event
Zoom ID: 910 4550 7427 Passcode: 776945

Sex differences in addiction are seen for all classes of abused drugs in humans and animal models. Females tend to be more susceptible to addiction-like behaviors and this is modulated by the ovarian hormone, estradiol. Estradiol enhances cocaine self-administration, and the cocaine-induced increase in dopamine in the striatum of female rats, but not male rats. Estradiol also enhances drug taking behavior and motivation for drugs of abuse in females. Interestingly, recent findings indicate that estradiol receptor subtypes differentially mediate specific aspects of motivation for drugs of abuse in a sex-dependent manner. These sex differences in the neural mechanisms of addiction have implications for interventions and treatment that will be discussed.

“Sex Differences in Motivated Behaviors: Lessons from Animal Models"

Jill Becker

Jill Becker, Ph.D.

Research Professor, Michigan Neuroscience Institute
Patricia Y. Gurin Collegiate Professor of Psychology, Chair of Biopsychology, Department of Psychology
Professor of Psychiatry, Department of Psychiatry
Senior Scholar, Neuroscience Program
Reproductive Sciences Program