Axons are the long, fragile, an energy hungry cellular projections of neurons critical for nervous system connectivity. Axons degenerate in a wide range of neurodegenerative conditions, resulting in irreversible neurological deficits. Axon degeneration is now believed to be controlled by an ancient auto-destruction pathway that revolves around the regulation of axonal bioenergetics. Previous therapeutic strategies specifically directed at the protection of injured axons have focused exclusively on neuronal components. However, whether axon-flanking glia regulate the stability of injured axons remained elusive. In this seminar, I will outline key results leading to our discoveries that Schwann cells and oligodendrocytes regulate the integrity of axons under physiological and injury conditions through metabolic crosstalk. These discoveries moving axonal and glial bioenergetics to center stage may guide novel therapeutic approaches to stabilize neuronal circuitry in neurodegenerative diseases.
Friday, April 23, 2021
Neurology/Neuroscience Research Seminar
12:00 PM to 1:00 PM
CME credit available, click here
Zoom ID: 910 4550 7427 Passcode: 776945