The seminar will provide an overview of the challenges in defining pathogenic mechanisms in a heterogeneous disease like amyotrophic lateral sclerosis (ALS), and how the use of patient derived samples helps identify genes and pathways that can then be further investigated in cell based or animal models of disease. Both unbiased and targeted proteomic methodologies have been used to discover biomarkers from human biofluids and pathways altered during ALS. Novel animal models have been generated to explore function consequences of disease causing MATR3 mutations, and initial efforts using precision medicine to treat ALS will be presented.
Friday, May 28, 2021
Neurology/Neuroscience Research Seminar
12:00 PM to 1:00 PM
CME credit available, click here
Meeting ID: 910 4550 7427 Passcode: 829259