Grand Rounds

Dr. Brett McCray is a physician scientist with training in neuromuscular disease and a background in cellular and molecular neuroscience. He is currently an Assistant Professor in Neurology at Johns Hopkins. He received his MD and PhD degrees from the University of Pennsylvania where he worked with Dr. J. Paul Taylor on the pathogenesis of hereditary neuropathy due to mutations in Rab7. He then completed neurology residency at the Mass General-Brigham Neurology program, followed by neuromuscular fellowship at Johns Hopkins. His current research focus is on Charcot-Marie-Tooth (CMT) disease and other forms of hereditary and acquired peripheral neuropathy. He serves as the co-director of the Johns Hopkins CMT clinic and the Johns Hopkins site PI for the Inherited Neuropathy Consortium genetics and natural history studies. His laboratory research is focused on the pathogenesis of hereditary neuropathy with a particular interest in CMT type 2C and related disorders that are caused by gain-of-function mutations in the cation channel TRPV4. He studies cellular and animal models of this disease, and he has also established a TRPV4 neuropathy patient registry and specialized multidisciplinary clinic to better define the natural history of the condition and to lay the foundation for a future clinical trial. His work on TRPV4 neuropathy was recently awarded the American Neurological Association Wolfe Research Prize for Identifying New Causes or Novel Treatments of Neuropathy.